Optical coherence tomography and electrophysiological analysis of proptotic eyes due to thyroid-associated ophthalmopathy.

Autor: Elsamkary MA; Faculty of Medicine, Ain Shams University, 11517 Ramses St. Abbassia, Cairo, Egypt., El-Shazly AAE; Faculty of Medicine, Ain Shams University, 11517 Ramses St. Abbassia, Cairo, Egypt., Badran TAF; Faculty of Medicine, Ain Shams University, 11517 Ramses St. Abbassia, Cairo, Egypt., Fouad YA; Faculty of Medicine, Ain Shams University, 11517 Ramses St. Abbassia, Cairo, Egypt. youseffouad@med.asu.edu.eg., Abdelgawad RHA; Faculty of Medicine, Ain Shams University, 11517 Ramses St. Abbassia, Cairo, Egypt.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2023 Jun; Vol. 43 (6), pp. 2057-2064. Date of Electronic Publication: 2022 Dec 08.
DOI: 10.1007/s10792-022-02605-x
Abstrakt: Purpose: To study the degree of morphological and functional changes in thyroid-associated ophthalmology (TAO) patients using optical coherence tomography and electrophysiological studies and investigate their clinical correlation.
Methods: A cross-sectional study including 40 patients with TAO and a control group with age- and sex-matched healthy subjects. All subjects underwent a complete ophthalmological examination, proptosis evaluation, spectral domain optical coherence tomography, and electrophysiological tests (pattern and multifocal electroretinograms, and visual evoked potentials).
Results: On multiple regression analysis, the degree of proptosis and P50 amplitude were the most important predictors of central foveal thickness (CFT) (β =  -  0.56 and 0.39 and p = 0.03 and 0.01, respectively); while duration of the disease, and clinical activity score (CAS) were the most important predictors of average RNFL thickness (β = 0.67 and  - 0.81 and p = 0.004 and  <  0.001, respectively).
Conclusion: In the absence of fundus changes, macular thinning along with functional alterations noticed by pattern and multifocal electroretinogram could indicate presence of subclinical retinopathy in TAO cases.
(© 2022. The Author(s).)
Databáze: MEDLINE
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