[Sarcopenia in patients with pancreatic cancer, an independant prognostic factor].
| Autor: | Mandl J; Klinik für Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Germany., Baumer S; Klinik für Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Germany., Holtzem B; Klinik für Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Germany., Theurer R; Institut für Radiologie, Neuroradiologie und Nuklearmedizin, Krankenhaus Barmherzige Bruder Regensburg, Regensburg, Germany., Zorger N; Institut für Radiologie, Neuroradiologie und Nuklearmedizin, Krankenhaus Barmherzige Bruder Regensburg, Regensburg, Germany., Pech O; Klinik für Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Germany. |
|---|---|
| Jazyk: | němčina |
| Zdroj: | Zeitschrift fur Gastroenterologie [Z Gastroenterol] 2023 Oct; Vol. 61 (10), pp. 1365-1370. Date of Electronic Publication: 2022 Dec 08. |
| DOI: | 10.1055/a-1959-2894 |
| Abstrakt: | Background: Pancreatic cancer is despite modern diagnostic tools and treatment regimen associated with poor outcome. Many patients show cachexia and sarcopenia. Methods: In a retrospective analysis the SMI (cm²/m²) was measured by determining the skelettal muscle area in a computed tomography image at lumbar vertebrae 3. Further clinical parameters were measured to determine the outcome. Results: The mean survival after diagnosis in the population with sarcopenia was significantly lower (14,4 vs 17,7 months, p=0,046). Significantly shorter survival was also seen for higher age (p=0,006), no tumor resection (p=0,004), metastases (p=0,002) and high CA19-9 level (p=0,002) CONCLUSION: Sarcopenia is an indipendant prognostic factor in patients with pancreatic cancer. SMI should be measured clinical practice and further studies are necessary to asses a potential therapeutic strategy. Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|