Gum Arabic nanoformulation rescues neuronal lesions in bromobenzene-challenged rats by its antioxidant, anti-apoptotic and cytoprotective potentials.

Autor: Almohaimeed HM; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, P.O. Box 84428, Saudi Arabia., Waly H; Laboratory of Physiology, Department of Zoology, Faculty of Sciences, Assiut University, Assiut, Egypt., Abou Khalil NS; Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, 71526, Egypt. nasser82@aun.edu.eg., Hassanein KMA; Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt., Alkhudhairy BSM; College of Medicine, Shaqra University, Riyadh 7396, P.O. Box 13343, Saudi Arabia., Abd-Allah EA; Department of Zoology, Faculty of Science, New Valley University, EL-Kharga, Egypt.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Dec 08; Vol. 12 (1), pp. 21213. Date of Electronic Publication: 2022 Dec 08.
DOI: 10.1038/s41598-022-24556-0
Abstrakt: Bromobenzene (BB) is a hazardous environmental contaminant because of its multiple routes of exposure and the toxicity of its bio-derivates. It could elicit neuronal alterations by stimulating redox imbalance and apoptotic pathways. Gum Arabic (GA) protected the hippocampus of a type 2 diabetic rat model from cognitive decline. Whether gum Arabic nanoemulsion (GANE) can increase the neuroprotectant potency of GA in fighting BB-associated neurological lesions is the question to be answered. To accomplish this objective, 25 adult male Wistar rats were randomly and equally assigned into five groups. Control received olive oil (vehicle of BB). BB group received BB at a dose of 460 mg/kg BW. Blank nanoemulsion (BNE) group supplemented with BNE at 2 mL of 10% w/v aqueous suspension/kg BW. GANE group received GANE at a dose of 2 mL of 10% w/v aqueous suspension/kg BW. BB + GANE group exposed to BB in concomitant with GANE at the same previous doses. All interventions were carried out daily by oral gavage for ten consecutive days. BB caused a marked increase in malondialdehyde and succinate dehydrogenase together with a marked decrease in reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and lactate dehydrogenase in the brain. BB was accompanied by pathological deteriorations, amyloidosis, and reduced immuno-expression of integrase interactor 1 in the hippocampal region. Administration of GANE was beneficial in reversing the aforementioned abnormalities. These results pave the road for further discovery of nano-formulated natural products to counter the threats of BB.
(© 2022. The Author(s).)
Databáze: MEDLINE
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