Recent Developments in Islet Biology: A Review With Patient Perspectives.

Autor: Basu L; Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada., Bhagat V; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Ching MEA; Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada., Di Giandomenico A; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Dostie S; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Greenberg D; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Greenberg M; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Hahm J; Department of Physiology and Pharmacology, Western University, London, Ontario, Canada., Hilton NZ; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Lamb K; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Jentz EM; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Larsen M; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Locatelli CAA; University of Ottawa Heart Institute, Energy Substrate Laboratory, Ottawa, Ontario, Canada; Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada., Maloney M; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., MacGibbon C; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Mersali F; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Mulchandani CM; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Najam A; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Singh I; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Weisz T; Diabetes Action Canada, Toronto General Hospital, Toronto, Ontario, Canada., Wong J; Alberta Diabetes Institute and Department of Pharmacology, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute and Department of Surgery, University of Alberta, Edmonton, Alberta, Canada., Senior PA; Alberta Diabetes Institute and Department of Medicine, Edmonton, Alberta, Canada., Estall JL; Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada; Institut de recherches cliniques de Montréal, Center for Cardiometabolic Health, Montréal, Québec, Canada., Mulvihill EE; University of Ottawa Heart Institute, Energy Substrate Laboratory, Ottawa, Ontario, Canada; Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada., Screaton RA; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Sunnybrook Research Institute, Toronto, Ontario, Canada. Electronic address: robert.screaton@sri.utoronto.ca.
Jazyk: angličtina
Zdroj: Canadian journal of diabetes [Can J Diabetes] 2023 Mar; Vol. 47 (2), pp. 207-221. Date of Electronic Publication: 2022 Nov 08.
DOI: 10.1016/j.jcjd.2022.11.003
Abstrakt: Navigating the coronavirus disease-2019 (COVID-19, now COVID) pandemic has required resilience and creativity worldwide. Despite early challenges to productivity, more than 2,000 peer-reviewed articles on islet biology were published in 2021. Herein, we highlight noteworthy advances in islet research between January 2021 and April 2022, focussing on 5 areas. First, we discuss new insights into the role of glucokinase, mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase and mitochondrial function on insulin secretion from the pancreatic β cell, provided by new genetically modified mouse models and live imaging. We then discuss a new connection between lipid handling and improved insulin secretion in the context of glucotoxicity, focussing on fatty acid-binding protein 4 and fetuin-A. Advances in high-throughput "omic" analysis evolved to where one can generate more finely tuned genetic and molecular profiles within broad classifications of type 1 diabetes and type 2 diabetes. Next, we highlight breakthroughs in diabetes treatment using stem cell-derived β cells and innovative strategies to improve islet survival posttransplantation. Last, we update our understanding of the impact of severe acute respiratory syndrome-coronavirus-2 infection on pancreatic islet function and discuss current evidence regarding proposed links between COVID and new-onset diabetes. We address these breakthroughs in 2 settings: one for a scientific audience and the other for the public, particularly those living with or affected by diabetes. Bridging biomedical research in diabetes to the community living with or affected by diabetes, our partners living with type 1 diabetes or type 2 diabetes also provide their perspectives on these latest advances in islet biology.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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