Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias.

Autor:	Yassine HN; Department of Medicine, Keck School of Medicine, University of Southern, California, Los Angeles, California, USA.; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Self W; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Kerman BE; Department of Medicine, Keck School of Medicine, University of Southern, California, Los Angeles, California, USA., Santoni G; Laboratory of Neuroepigenetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland., Navalpur Shanmugam N; Department of Neurology, Genetics and Aging Research Unit, McCance Center for Brain Health, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Abdullah L; Roskamp Institute, Sarasota, Florida, USA., Golden LR; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA., Fonteh AN; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Huntington Medical Research Institutes, Pasadena, California, USA., Harrington MG; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Gräff J; Laboratory of Neuroepigenetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland., Gibson GE; Brain and Mind Research Institute, Weill Cornell Medicine, Burke Neurological Institute, White Plains, New York, USA., Kalaria R; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Luchsinger JA; Department of Medicine and Epidemiology, Columbia University Irving Medical Center, New York City, New York, USA., Feldman HH; Department of Neurosciences, University of California, San Diego, California, USA., Swerdlow RH; Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas, USA., Johnson LA; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA., Albensi BC; Nova Southeastern Univ. College of Pharmacy, Davie, Florida, USA.; Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada., Zlokovic BV; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Tanzi R; Department of Neurology, Genetics and Aging Research Unit, McCance Center for Brain Health, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Cunnane S; Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada., Samieri C; Univ. Bordeaux, INSERM, BPH, U1219, F-33000, Bordeaux, France., Scarmeas N; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Department of Neurology, Columbia University, New York City, New York, USA., Bowman GL; Department of Neurology, Genetics and Aging Research Unit, McCance Center for Brain Health, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Helfgott Research Institute, National University of Natural Medicine, Portland, Oregon, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Mar; Vol. 19 (3), pp. 1041-1066. Date of Electronic Publication: 2022 Dec 08.
DOI:	10.1002/alz.12845
Abstrakt:	Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify deficits in cerebral bioenergetics may therefore offer novel therapeutic potential for Alzheimer's disease (AD) prevention and management. Many diet-derived natural bioactive components can govern cellular energy metabolism but their effects on brain aging are not clear. This review examines how nutritional metabolism can regulate brain bioenergetics and mitigate AD risk. We focus on leading mechanisms of cerebral bioenergetic breakdown in the aging brain at the cellular level, as well as the putative causes and consequences of disturbed bioenergetics, particularly at the blood-brain barrier with implications for nutrient brain delivery and nutritional interventions. Novel therapeutic nutrition approaches including diet patterns are provided, integrating studies of the gut microbiome, neuroimaging, and other biomarkers to guide future personalized nutritional interventions. (© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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