Virulence-Related Transcriptional Regulators of Streptococcus pyogenes
| Autor: | Vega LA; Dept. of Pediatrics, University of Texas Health Sciences Center at Houston, TX, USA, Malke H; Friedrich-Schiller Universität, Jena, Germany, and Oklahoma University Health Sciences Center, Oklahoma City, OK, USA, McIver KS; Dept. of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA |
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| Jazyk: | angličtina |
| Zdroj: | 2022 Oct 08. |
| Abstrakt: | Control of virulence gene expression in S. pyogenes is under the charge of 13 two-component regulatory systems and at least 30 transcriptional regulators known thus far. These virulence-related regulators are tasked with integrating environmental host cues with the pathogen’s own metabolic state, as well as feedback signals from the expressed genome, into a coordinated response. This overview of the current understanding of S. pyogenes virulence-related regulators describes their roles in one or multiple of the following categories: Master regulators , such as CovR/S, RocA, LiaS/F/R, and RofA-like proteins (RALPs), that control the activity of multiple virulence-related regulators; Metabolite-responsive regulators , which sense and respond to changes in availability of sources of energy ; carbohydrates (CcpA, Mga), amino acid/nitrogen supplies (Rsh, CodY), and other metabolites S. pyogenes must monitor in the host; Metabolic-control regulators, such as VicR/S, MtsR, CiaH/R, that influence expression of metabolism-related genes to maintain the necessary homeostasis to promote colonization; and Environmental/host immunity-responsive regulators , which control responses to a variety of cues, like oxidative stress (PerR, CiaH/R), quorum sensing (Rgg2/3, Sil), saliva (SalK/R, SptR/S), blood, and neutrophils (Ihk/Irr, CovR/S, LiaS/F/R). Emphasis is made on the interdependence among regulators and the ways in which variation in their connectivity depends on their genotypic background, likely due to coevolution with its human host. (© The University of Oklahoma Health Sciences Center.) |
| Databáze: | MEDLINE |
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