Reliability of algebraic sum to evaluate adjuvant pelvic radiotherapy and vaginal cuff brachytherapy cumulative doses in uterine cancers.

Autor: Casale M; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Draghini L; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Trippa F; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Costantini S; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Vicenzi L; Radiation Oncology Centre, Ospedali Riuniti Umberto I, Ancona, Italy., Tesei L; Radiation Oncology Centre, Ospedali Riuniti Umberto I, Ancona, Italy., Di Marzo A; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Arcidiacono F; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Italiani M; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy., Maranzano E; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy.; Department of Medicine and Surgery, University of Perugia, Italy.
Jazyk: angličtina
Zdroj: Journal of contemporary brachytherapy [J Contemp Brachytherapy] 2022 Oct; Vol. 14 (5), pp. 470-475. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.5114/jcb.2022.121175
Abstrakt: Purpose: To evaluate the reliability of algebraic sum with respect to rigid fusion of treatment plans related to adjuvant external beam pelvic radiotherapy (APR) and vaginal cuff high-dose-rate brachytherapy (BT) in uterine cancer patients.
Material and Methods: For algebraic sum, APR and BT doses were mathematically added. Rigid fusion was realized overlapping computed tomography (CT) images of APR and BT treatment plans. Rectum and bladder were considered reference organs at risk (OARs). Following dose (D) parameters were examined: D max (0.5 cc), D 20% and D 50% for rectum, D max (0.5 cc) and D 50% for bladder; for each parameter, differences between the two adopted methods were reported as Δ-values.
Results: Twenty uterine cancer patients submitted to radical surgery followed by APR plus vaginal cuff BT were reviewed. APR was done with a dose of 25 × 2 Gy. All patients also receveid a vaginal cuff boost with BT at the dose of 2 × 5 Gy. Differences between mean cumulative doses calculated with rigid fusion and algebraic sum were evaluated. For the rectum and bladder ΔD 50% , there were no significant differences, and BT contribution resulted minimal. An apparent significant difference value was registered in bladder ΔD max (0.5 cc). No toxicity was observed.
Conclusions: In uterine cancer patients submitted to APR and vaginal cuff BT, algebraic sum and rigid plan fusion of doses allowed to obtain similar results in evaluating cumulative OARs' doses. Further investigations and increased number of patients are recommended to confirm our findings.
Competing Interests: The authors report no conflict of interest.
(Copyright © 2022 Termedia.)
Databáze: MEDLINE
Externí odkaz: