| Autor: |
Araujo FO; Universidade Federal de Viçosa, Departmento de Bioquímica e Biologia Molecular, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Felício MB; Universidade Federal de Viçosa, Departmento de Bioquímica e Biologia Molecular, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Lima CF; Instituto Federal de Educação do Pará, Campus Óbidos, Avenida Nelson Souza, s/n, Distrito Industrial, 68250-000 Óbidos, PA, Brazil., Piccolo MS; Universidade Federal de Viçosa, Departmento de Bioquímica e Biologia Molecular, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Pizziolo VR; Universidade Federal de Viçosa, Departmento de Bioquímica e Biologia Molecular, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Diaz-Muñoz G; Universidade Federal de Minas Gerais, Departmento de Química, Avenida Antônio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil., Bastos DSS; Universidade Federal de Viçosa, Departmento de Biologia Geral, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Oliveira LL; Universidade Federal de Viçosa, Departmento de Biologia Geral, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Peluzio MDCG; Universidade Federal de Viçosa, Departmento de Nutrição e Saúde, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil., Diaz MAN; Universidade Federal de Viçosa, Departmento de Bioquímica e Biologia Molecular, Avenida P.H. Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil. |
| Abstrakt: |
Inflammatory bowel diseases are a group of inflammatory disorders of the gastrointestinal tract. Their prevalence is still low in Brazil, but the incidence is increasing annually. A variety of compounds present in Curcuma longa L., particularly curcumin, have been shown to reduce oxidative stress and aid in the prevention of associated diseases. This study aimed to assess the effect of curcumin transdermal gel on oxidative stress and intestinal inflammation in IL-10 knockout mice. Female mice were divided into four groups: a control group (C0) treated with vehicle and three experimental groups treated with transdermal gel containing 50 (C50), 75 (C75), and 100 (C100) mg curcumin kg-1 body weight. Colon malondialdehyde concentrations were lower in C50 and C75 groups. C100 treatment led to reduced catalase activity in the small intestine, whereas C50, C75, and C100 treatments resulted in decreased catalase activity in the colon. In contrast, superoxide dismutase activity increased in the small intestine of C50 and C75 mice and decreased in the colon of C50, C75, and C100 mice. Glutathione S-transferase activity increased in the small intestine and decreased in the colon of C75 animals. These findings suggest that curcumin transdermal gel exerts a protective effect against oxidative stress. |
