Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring.

Autor:	Moussavi M; Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX, USA., Cuskelly A; Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle, Callaghan, NSW, Australia., Jung Y; Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX, USA., Hodgson DM; Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle, Callaghan, NSW, Australia., Barouei J; Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX, USA.; Integrated Food Security Research Center, Prairie View A&M University, Prairie View, TX, USA.
Jazyk:	angličtina
Zdroj:	Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2023 Feb 24; Vol. 87 (3), pp. 308-313.
DOI:	10.1093/bbb/zbac199
Abstrakt:	Corticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions. (© The Author(s) 2022. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
Databáze:	MEDLINE
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