Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease.

Autor: Ersoezlue E; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Rauchmann BS; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UK., Schneider-Axmann T; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Ballarini T; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Tato M; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Utecht J; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Kurz C; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Papazov B; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Guersel S; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Burow L; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Koller G; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Stöcklein S; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Keeser D; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Bartels C; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Cetindag AC; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Dechent P; MR-Research in Neurology and Psychiatry, Georg-August-University Göttingen, Germany., Dobisch L; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Ewers M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Frommann I; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Haynes JD; Bernstein Center for Computational Neuroscience, Charité - Universitätsmedizin, Berlin, Germany., Heneka MT; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Janowitz D; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kleinedam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Maier F; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Metzger CD; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany., Munk MH; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Peters O; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Preis L; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany; Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Roeske S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Roy N; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, University of Bonn, Bonn, Germany., Spruth EJ; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Wolfsgruber S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Germany., Yakupov R; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Duezel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany., Perneczky R; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK; Sheffield Institute for Translational Neurology (SITraN), University of Sheffield, Sheffield, UK. Electronic address: robert.perneczky@med.lmu.de.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Feb; Vol. 122, pp. 33-44. Date of Electronic Publication: 2022 Oct 23.
DOI: 10.1016/j.neurobiolaging.2022.05.015
Abstrakt: Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-β (Aβ) negative healthy controls and 152 Aβ positive individuals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by education and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively intact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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