Pharmacological applications of nitric oxide-releasing biomaterials in human skin.

Autor: Seabra AB; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil. Electronic address: amedea.seabra@ufabc.edu.br., Pieretti JC; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil., de Melo Santana B; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil., Horue M; Laboratorio de Nanobiomateriales, CINDEFI - Facultad de Ciencias Exactas, Universidad Nacional de La Plata- CONICET (CCT La Plata), Argentina., Tortella GR; Department of Chemical Engineering, Universidad de La Frontera, Temuco, Chile; Centro de Excelencia en Investigación Biotecnologica Aplicada al Medio Ambiente (CIBAMA-BIOREN), Universidad de La Frontera, Temuco, Chile., Castro GR; Nanobiotechnology Area, Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC). Partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC, MPG) - CONICET. Maipú 1065, S2000 Rosario, Santa Fe, Argentina; Nanomedicine Research Unit (Nanomed), Center for Natural and Human Sciences (CCNH), Universidade Federal do ABC (UFABC), Santo André, SP, Brazil. Electronic address: guillermo.castro@ufabc.edu.br.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2023 Jan 05; Vol. 630, pp. 122465. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.1016/j.ijpharm.2022.122465
Abstrakt: Nitric oxide (NO) is an important endogenous molecule that plays several roles in biological systems. NO is synthesized in human skin by three isoforms of nitric oxide synthase (NOS) and, depending on the produced NO concentration, it can actuate in wound healing, dermal vasodilation, or skin defense against different pathogens, for example. Besides being endogenously produced, NO-based pharmacological formulations have been developed for dermatological applications targeting diverse pathologies such as bacterial infection, wound healing, leishmaniasis, and even esthetic issues such as acne and skin aging. Recent strategies focus mainly on developing smart NO-releasing nanomaterials/biomaterials, as they enable a sustained and targeted NO release, promoting an improved therapeutic effect. This review aims to overview and discuss the main mechanisms of NO in human skin, the recent progress in the field of dermatological formulations containing NO, and their application in several skin diseases, highlighting promising advances and future perspectives in the field.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Amedea B. Seabra reports financial support was provided by State of Sao Paulo Research Foundation. Joana C. Pieretti reports financial support was provided by State of Sao Paulo Research Foundation. Bianca de Melo Santana reports financial support was provided by State of Sao Paulo Research Foundation. Gonzalo R Tortella reports financial support was provided by University of the Frontier. Guillermo R. Castro reports financial support was provided by National Research Council (CONICET) of Argentina. Amedea B. Seabra reports financial support was provided by National Council for Scientific and Technological Development.].
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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