Assessing Neurocognition (P300) and Correlating Them to Depression Rating Scales in Patients With Major Depressive Disorder.

Autor:	Wakode S; Physiology, All India Institute of Medical Sciences, Bhopal, IND., Hulke S; Physiology, All India Institute of Medical Sciences, Bhopal, IND., Wakode NS; Anatomy, Atal Bihari Vajpayee Government Medical College, Vidisha, IND., Pathak T; Physiology, All India Institute of Medical Sciences, Bhopal, IND., Shrivastava R; Physiology, All India Institute of Medical Sciences, Bhopal, IND., Thakare A; Physiology, All India Institute of Medical Sciences, Bhopal, IND., Malhotra V; Physiology, All India Institute of Medical Sciences, Bhopal, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Nov 04; Vol. 14 (11), pp. e31084. Date of Electronic Publication: 2022 Nov 04 (Print Publication: 2022).
DOI:	10.7759/cureus.31084
Abstrakt:	Background: Major depression is a chronic condition that may affect cognition. Cognitive disturbances may affect clinical scales used to assess the severity of depression. Aims: To find an association between cognitive disturbance as objectively recorded using event-related potentials (P300) with the Hamilton rating scale for depression (HAM-D) and Montgomery-Asberg depression rating scale (MADRS) in newly diagnosed cases of major depression. Methods and Material: A cross-sectional study with a sample size of 46 diagnosed cases of major depression. The assessment was done using the HAM-D and MADRS. The P300 assessment was done with the auditory oddball paradigm using the Nihon Kohden NCV-SMG-EP system (Tokyo, Japan). Statistical Analysis: Pearson correlation analysis was used to study the association between various parameters of P300 and the HAM-D and MADRS depression rating scales. Results: A significant correlation was found between A21- P300 amplitude Cz and the MADRS score. No significant correlation was seen between other P300 parameters and HAM-D and MADRS scales. Conclusions: As the results were objectively recorded using various parameters of event-related potentials (P300), cognitive impairment was not significantly associated with depression rating scales i.e., the HAM-D and MADRS scores. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Wakode et al.)
Databáze:	MEDLINE
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