Screening of Selected Stingless Bee Honey Varieties for ACE2-Spike Protein-Binding Inhibition Activity: A Potential Preventive Medicine Against SARS-Cov-2 Infection.

Autor: Arung ET; Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia.; Research Center for Drugs and Cosmetics from Tropical Rainforest Resources, Mulawarman University, Samarinda, Indonesia., Ramadhan R; Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia.; Division of Exploration and Synthesis of Bioactive Compounds, Research Center for Bio-Molecule Engineering, Airlangga University, Surabaya, Indonesia., Mandzilkh LD; Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia., Santoso PA; Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia., Matsumoto M; Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan., Nagata M; Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan., Kusuma IW; Laboratory of Forest Product Chemistry, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia., Paramita S; Research Center for Drugs and Cosmetics from Tropical Rainforest Resources, Mulawarman University, Samarinda, Indonesia.; Department of Community Medicine, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia., Sukemi; Chemical Education Program, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, Indonesia., Yadi; Department of Microbiology, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia., Takemoto N; Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan., Amen Y; Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Syafrizal; Department of Biology, Faculty of Mathematics and Science, Mulawarman University, Samarinda, Indonesia., Shimizu K; Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.; Institute for Asian and Oceanian Studies, Kyushu University, Fukuoka, Japan., Tandirogang N; Department of Microbiology, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia.
Jazyk: angličtina
Zdroj: The Malaysian journal of medical sciences : MJMS [Malays J Med Sci] 2022 Oct; Vol. 29 (5), pp. 146-153. Date of Electronic Publication: 2022 Oct 28.
DOI: 10.21315/mjms2022.29.5.15
Abstrakt: The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 samples of honey from 11 species of stingless bees using an angiotensin-converting enzyme 2 (ACE2)-spike protein-binding assay and phytochemical analysis. Ten of the samples showed inhibition above 50% in this assay system. Most of the honey contained tannins, alkaloids, flavonoids, triterpenoids, carotenoids and carbohydrates. Our findings in this in vitro study showed that honey from stingless bees may have a potent effect against SARS-CoV-2 infection by inhibiting the ACE2-spike protein-binding.
Competing Interests: Conflict of Interest None.
(© Penerbit Universiti Sains Malaysia, 2022.)
Databáze: MEDLINE
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