Artificial genetic polymers against human pathologies.

Autor: Ivanov GS; Institute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, Russia, 194064.; St. Petersburg State Technological Institute (Technical University), Saint Petersburg, Russia, 190013., Tribulovich VG; St. Petersburg State Technological Institute (Technical University), Saint Petersburg, Russia, 190013., Pestov NB; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow, Russia, 108819.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia, 141701.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia, 117997.; Institute of Biomedical Chemistry, Moscow, Russia, 119121б., David TI; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia, 141701., Amoah AS; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia, 141701., Korneenko TV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia, 117997., Barlev NA; Institute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, Russia, 194064. nick.a.barlev@gmail.com.; Institute of Biomedical Chemistry, Moscow, Russia, 119121б. nick.a.barlev@gmail.com.; School of Medicine, Nazarbayev University, 010000, Astana, Kazakhstan. nick.a.barlev@gmail.com.
Jazyk: angličtina
Zdroj: Biology direct [Biol Direct] 2022 Dec 06; Vol. 17 (1), pp. 39. Date of Electronic Publication: 2022 Dec 06.
DOI: 10.1186/s13062-022-00353-7
Abstrakt: Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.
(© 2022. The Author(s).)
Databáze: MEDLINE
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