Effect of Environmental Stressors, Xenobiotics, and Oxidative Stress on Male Reproductive and Sexual Health.

Autor:	Madhu NR; Department of Zoology, Acharya Prafulla Chandra College, New Barrackpore, Kolkata, West Bengal, India., Sarkar B; Department of Botany, Acharya Prafulla Chandra College, New Barrackpore, Kolkata, West Bengal, India., Slama P; Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic., Jha NK; Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, India., Ghorai SK; Department of Zoology, Egra SSB College, Purba Medinipur, West Bengal, India., Jana SK; Department of Zoology, Bajkul Milani Mahavidyalaya, Purba Medinipur, West Bengal, India., Govindasamy K; Animal Production Division, ICAR Research Complex for NEH Region, Indian Council of Agricultural Research, Umiam, Meghalaya, India., Massanyi P; Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic., Lukac N; Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic., Kumar D; School of Health Sciences & Technology, UPES University, Dehradun, Uttarakhand, India., Kalita JC; Department of Zoology, Gauhati University, Guwahati, India., Kesari KK; Department of Applied Physics, School of Science, Aalto University, Espoo, Finland., Roychoudhury S; Department of Life Science and Bioinformatics, Assam University, Silchar, India. shubhadeep1@gmail.com.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2022; Vol. 1391, pp. 33-58.
DOI:	10.1007/978-3-031-12966-7_3
Abstrakt:	This article examines the environmental factor-induced oxidative stress (OS) and their effects on male reproductive and sexual health. There are several factors that induce OS, i.e. radition, metal contamination, xenobiotic compounds, and cigarette smoke and lead to cause toxicity in the cells through metabolic or bioenergetic processes. These environmental factors may produce free radicals and enhance the reactive oxygen species (ROS). Free radicals are molecules that include oxygen and disbalance the amount of electrons that can create major chemical chains in the body and cause oxidation. Oxidative damage to cells may impair male fertility and lead to abnormal embryonic development. Moreover, it does not only cause a vast number of health issues such as ageing, cancer, atherosclerosis, insulin resistance, diabetes mellitus, cardiovascular diseases, ischemia-reperfusion injury, and neurodegenerative disorders but also decreases the motility of spermatozoa while increasing sperm DNA damage, impairing sperm mitochondrial membrane lipids and protein kinases. This chapter mainly focuses on the environmental stressors with further discussion on the mechanisms causing congenital impairments due to poor sexual health and transmitting altered signal transduction pathways in male gonadal tissues. (© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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