HIV-associated nephropathy in children: challenges in a resource-limited setting.

Autor: Nkoy AB; Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium., Ekulu PM; Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Labarque V; Department of Pediatric Hematology, University Hospital Leuven, Leuven, Belgium.; Center of Molecular and Vascular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium., Van den Heuvel LP; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.; Department of Pediatric Nephrology, Radboud University Medical Centre, Nijmegen, Netherlands., Levtchenko EN; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium. elena.levtchenko@uzleuven.be.; Department of Pediatric Nephrology, University Hospital Leuven, Leuven, Belgium. elena.levtchenko@uzleuven.be.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2023 Aug; Vol. 38 (8), pp. 2509-2521. Date of Electronic Publication: 2022 Dec 06.
DOI: 10.1007/s00467-022-05819-4
Abstrakt: HIV infection remains one of the leading causes of morbidity and mortality worldwide, especially in children living in resource-limited settings. Although the World Health Organization (WHO) recently recommended antiretroviral therapy (ART) initiation upon diagnosis regardless of the number of CD4, ART access remains limited, especially in children living in sub-Saharan Africa (SSA). HIV-infected children who do not receive appropriate ART are at increased risk of developing HIV-associated nephropathy (HIVAN). Although due to genetic susceptibility, SSA is recognized to be the epicenter of HIVAN, limited information is available regarding the burden of HIVAN in children living in Africa. The present review discusses the information available to date on the prevalence, pathogenesis, risk factors, diagnosis, and management of HIVAN in children, focusing on related challenges in a resource-limited setting.
(© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
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