Aerococcus urinae - significance of detection in the paediatric urinary tract: a case series.

Autor: Rast D; University Children's Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland. dimitri.rast@ukbb.ch., Evers KS; University Children's Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland.; Paediatric Nephrology, University Children's Hospital Basel, Basel, Switzerland., Egli A; Division of Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.; Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Rudin C; University Children's Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland.; Paediatric Nephrology, University Children's Hospital Basel, Basel, Switzerland., Goischke A; University Children's Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland.; Paediatric Nephrology, University Children's Hospital Basel, Basel, Switzerland., Ritz N; University Children's Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland.; Paediatric Infectious Diseases and Vaccinology, University Children's Hospital Basel, Basel, Switzerland.; Department of Paediatrics and Paediatric Infectious Diseases, Children's Hospital, Lucerne Cantonal Hospital, Lucerne, Switzerland.; Department of Paediatrics, The Royal Children's Hospital Melbourne, The University of Melbourne, Melbourne, Australia.
Jazyk: angličtina
Zdroj: European journal of pediatrics [Eur J Pediatr] 2023 Feb; Vol. 182 (2), pp. 749-756. Date of Electronic Publication: 2022 Dec 06.
DOI: 10.1007/s00431-022-04730-2
Abstrakt: Aerococcus urinae (A. urinae) is primarily recognized as a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients. In the paediatric population, only a few case reports exist suggesting A. urinae causes malodorous urine in otherwise healthy boys. In this study, we investigated the spectrum of clinical and laboratory presentations of A. urinae detection in children. A retrospective, single-centre, case series including all patients with the detection of A. urinae during a 7-year study period. Patients with detection of A. urinae only in non-urogenital skin swabs were excluded. A total of 40 samples from 33 patients were identified of which 20 patients were included in the final analysis. The median (IQR) age was 6.8 (2.9-9.5) years; 18 (90%) patients were boys. Four patients were diagnosed with a UTI, six had malodorous urine without UTI, three were diagnosed with balanitis and seven showed A. urinae colonization in the urine culture. Urogenital disorders were present in 12 patients. Additional pathogens were detected in 13 patients. Recurrence of detection during our study period was observed in four (20%) patients.  Conclusion: Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population. Pre-existing urogenital disorders were frequent, and therefore, a nephro-urological investigation should be considered in all cases of A. urinae detection in the paediatric population. What is Known: • Aerococcus urinae (A. urinae) is known to be a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients. • In the paediatric population, A. urinae is mainly described as a low-grade pathogen. Some case reports describe A. urinae as the cause of extraordinary malodorous urine in otherwise healthy boys. What is New: • Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population. • A. urinae was mainly detected in boys with pre-existing urogenital disorders; therefore, a nephro-urological investigation should be considered in cases of A. urinae detection in the paediatric population.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje