Gut microbiota-derived metabolite trimethylamine N-oxide and biomarkers of inflammation are linked to endothelial and coronary microvascular function in patients with inflammatory bowel disease.

Autor: Kul S; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Caliskan Z; Gastroenterology Department, Istanbul Umraniye Training and Research Hospital, Istanbul, Turkey., Guvenc TS; Department of Cardiology, Istinye University Faculty of Medicine, Istanbul, Turkey., Celik FB; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Sarmis A; Department of Medical Microbiology Laboratory, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Atici A; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Konal O; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Akıl M; Department of Parasitology, Faculty of Medicine, Istanbul Medeniyet University, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Cumen AS; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Bilgic NM; Gastroenterology Department, Istanbul Umraniye Training and Research Hospital, Istanbul, Turkey., Yilmaz Y; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey., Caliskan M; Cardiology Department, Istanbul Medeniyet University, Faculty of Medicine, Prof Dr Suleyman Yalcin City Hospital, Dr. Erkin street, 34722 Istanbul, Turkey. Electronic address: caliskandr@gmail.com.
Jazyk: angličtina
Zdroj: Microvascular research [Microvasc Res] 2023 Mar; Vol. 146, pp. 104458. Date of Electronic Publication: 2022 Nov 26.
DOI: 10.1016/j.mvr.2022.104458
Abstrakt: Background: Inflammatory bowel disease (IBD), which is an umbrella term used for ulcerative colitis (UC) and Crohn's disease (CD), is associated with an increased risk for atherosclerotic cardiovascular disease (CVD). We aimed to investigate the association of local and systemic biomarkers of inflammation and gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) with endothelial and coronary microvascular dysfunction in IBD.
Methods: A total of 56 patients with IBD (20 with UC and 36 with CD) and 34 age and gender matched controls were included. For all participants, samples were collected to analyze faecal calprotectin, and TMAO concentrations. Ultrasound-based examinations were done to measure flow-mediated vasodilatation (FMD) and coronary flow velocity reserve (CFVR).
Results: Patients with IBD had lower CFVR (2.07 (1.82-2.40)) and FMD (8.7 ± 3.7) as compared to controls (2.30 (2.07-2.74), p = 0.005 and 11.9 ± 6.8, p = 0.03). In patients with IBD, TMAO concentration (r = -0.30, p = 0.03), C-reactive protein (r = -0.29, p = 0.03) and WBC count (r = -0.37, p = 0.006) had a significant negative correlation with CFVR, and TMAO (β = -0.27, 95 % CI: -0.23 to -0.02) and WBC count (β = -0.31, 95 % CI: -0.56 to -0.06) were significant predictors of CFVR after multivariate adjustment. None of the biomarkers of inflammation or TMAO showed significant correlations with FMD. In patients with UC, TMAO showed a significant correlation with both CFVR (r = -0.55, p = 0.01) and FMD (r = -0.60, p = 0.005) while only WBC count had a statistically significant correlation with CFVR (r = -0.49, p = 0.004) in patients with CD.
Conclusions: Gut microbiota-derived metabolite TMAO and biomarkers of systemic inflammation are associated with measures of endothelial/coronary microvascular dysfunction in patients with IBD.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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