Clinical-epidemiological characteristics and maternal-foetal outcomes in pregnant women hospitalised with COVID-19 in Venezuela: a retrospective study.

Autor: Carrión-Nessi FS; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela. fhabiancarrion@gmail.com.; 'Dr. Francisco Battistini Casalta' Health Sciences School, University of Oriente - Bolivar Nucleus, Ciudad Bolivar, Venezuela. fhabiancarrion@gmail.com., Castro MP; Obstetrics and Gynaecology Department, San Cristobal Central Hospital, San Cristobal, Venezuela., Freitas-De Nobrega DC; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela.; 'Dr. Francisco Battistini Casalta' Health Sciences School, University of Oriente - Bolivar Nucleus, Ciudad Bolivar, Venezuela., Moncada-Ortega A; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela.; 'José María Vargas' School of Medicine, Central University of Venezuela, Caracas, Venezuela., Omaña-Ávila ÓD; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela.; 'Luis Razetti' School of Medicine, Central University of Venezuela, Caracas, Venezuela., Mendoza-Millán DL; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela.; 'Luis Razetti' School of Medicine, Central University of Venezuela, Caracas, Venezuela., Marcano-Rojas MV; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela., Trejo NJ; 'Dr. Francisco Battistini Casalta' Health Sciences School, University of Oriente - Bolivar Nucleus, Ciudad Bolivar, Venezuela., Virriel IV; 'Dr. Francisco Battistini Casalta' Health Sciences School, University of Oriente - Bolivar Nucleus, Ciudad Bolivar, Venezuela., Chavero M; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela., Camejo-Ávila NA; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela.; 'Dr. Francisco Battistini Casalta' Health Sciences School, University of Oriente - Bolivar Nucleus, Ciudad Bolivar, Venezuela., Rodriguez-Morales AJ; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Américas - Institución Universitaria Visión de Las Américas, Pereira, Risaralda, Colombia.; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon.; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru., Forero-Peña DA; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela. vacter.cv@gmail.com.; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela. vacter.cv@gmail.com.
Jazyk: angličtina
Zdroj: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2022 Dec 05; Vol. 22 (1), pp. 905. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.1186/s12884-022-05253-2
Abstrakt: Background: In low- and middle-income countries, pregnant women and newborns are more vulnerable to adverse outcomes from coronavirus disease 2019 (COVID-19). However, in Venezuela, there are no integrated data in a national surveillance system to identify the clinical-epidemiological characteristics and maternal-foetal outcomes of pregnant women hospitalised with COVID-19.
Methods: A retrospective study was conducted among Venezuelan pregnant women hospitalised with COVID-19 seen at the "Ruiz y Páez" University Hospital Complex and the San Cristobal Central Hospital between June 2020 and September 2021. Information was obtained from physical and digitised clinical records using a purpose-designed proforma to collect epidemiological, clinical, paraclinical, treatment, obstetric and perinatal complications, and maternal-foetal outcomes data.
Results: A total of 80 pregnant women with confirmed severe acute respiratory syndrome coronavirus 2 infection were seen within the study period, 59 (73.8%) survived and 21 (26.2%) died. The median (interquartile range) age was 29 (23-33) years, the majority being in the third trimester of pregnancy (81.2%; n = 65). Interestingly, four (5%) pregnant women were co-infected with malaria by Plasmodium vivax and three (3.8%) with syphilis. The most frequent symptoms were fever (75%; n = 60), dry cough (68.8%; n = 55), dyspnoea (55%; n = 44), and headache (53.8%; n = 43). The most frequent maternal complications were anaemia (51.5%; n = 66) and hypertensive disorders of pregnancy (17.5%; n = 14). The most frequent perinatal complications were preterm delivery (39.2%; n = 20/51) and oligohydramnios (31.3%; n = 25). A total of 29 (36.3%) adverse foetal outcomes were documented, 21 stillbirth and eight abortions.
Conclusion: This is the first study to describe the clinical-epidemiological behaviour of COVID-19 in hospitalised Venezuelan pregnant women. Anaemia, hypertensive disorders of pregnancy, oligohydramnios, and low birth weight were the most frequent maternal-foetal complications in this population of pregnant women.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje