5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development.

Autor: Higa GSV; Departamento de Fisiologia e Biofísica, Laboratório de Neurofisiologia, Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil. guisvhiga@gmail.com.; Laboratório de Neurogenética, Universidade Federal do ABC, São Bernardo do Campo, SP, 09606-045, Brazil. guisvhiga@gmail.com.; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, (USP), Butantã, São Paulo, SP, 05508-900, Brazil. guisvhiga@gmail.com., Francis-Oliveira J; Departamento de Fisiologia e Biofísica, Laboratório de Neurofisiologia, Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil., Carlos-Lima E; Departamento de Fisiologia e Biofísica, Laboratório de Neurofisiologia, Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil., Tamais AM; Departamento de Fisiologia e Biofísica, Laboratório de Neurofisiologia, Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil., Borges FDS; Postdoctoral research, Department of Physiology & Pharmacology, SUNY Downstate Health Sciences Brooklyn, Brooklyn, NY, 11203, USA.; PDC, Center for Mathematics Computation and Cognition, Universidade Federal do ABC, São Bernardo do Campo, Brazil., Kihara AH; Laboratório de Neurogenética, Universidade Federal do ABC, São Bernardo do Campo, SP, 09606-045, Brazil., Shieh IC; Departamento de Fisiologia e Biofísica, Laboratório de Neurofisiologia, Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil., Ulrich H; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, (USP), Butantã, São Paulo, SP, 05508-900, Brazil., Chiavegatto S; Laboratório de Neurociência Comportamental e Molecular, Departamento de Farmacologia, Instituto de Ciências Biomédicas (ICB), Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil.; Departamento de Psiquiatria, Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, 05508-903, Brazil., De Pasquale R; Departamento de Fisiologia e Biofísica, Laboratório de Neurofisiologia, Universidade de São Paulo (USP), Butantã, São Paulo, SP, 05508-000, Brazil. robertode@usp.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Dec 05; Vol. 12 (1), pp. 21015. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.1038/s41598-022-23767-9
Abstrakt: Important functions of the prefrontal cortex (PFC) are established during early life, when neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage drives the organization of cortical connectivity, responsible for establishing behavioral patterns. Serotonin (5-HT) emerges among the most significant factors that modulate brain activity during postnatal development. In the PFC, activated 5-HT receptors modify neuronal excitability and interact with intracellular signaling involved in synaptic modifications, thus suggesting that 5-HT might participate in early postnatal plasticity. To test this hypothesis, we employed intracellular electrophysiological recordings of PFC layer 5 neurons to study the modulatory effects of 5-HT on plasticity induced by theta-burst stimulation (TBS) in two postnatal periods of rats. Our results indicate that 5-HT is essential for TBS to result in synaptic changes during the third postnatal week, but not later. TBS coupled with 5-HT 2A or 5-HT 1A and 5-HT 7 receptors stimulation leads to long-term depression (LTD). On the other hand, TBS and synergic activation of 5-HT 1A , 5-HT 2A , and 5-HT 7 receptors lead to long-term potentiation (LTP). Finally, we also show that 5-HT dependent synaptic plasticity of the PFC is impaired in animals that are exposed to early-life chronic stress.
(© 2022. The Author(s).)
Databáze: MEDLINE
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