Molecular identification and virological characteristics of highly pathogenic avian influenza A/H5N5 virus in wild birds in Egypt.

Autor: Kandeil A; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Kayed A; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., Moatasim Y; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., Aboulhoda BE; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt., El Taweel AN; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., Kutkat O; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., El Sayes M; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., Gomaa M; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., El-Shesheny R; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt., Webby R; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Kayali G; Human Link, Dubai, United Arab Emirates. Electronic address: ghazi@human-link.org., Ali MA; Center of Scientific Excellence for Influenza Virus, National Research Centre, Giza, 12622, Egypt. Electronic address: mohamedahmedali2004@yahoo.com.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2023 Jan; Vol. 174, pp. 105928. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.1016/j.micpath.2022.105928
Abstrakt: Multiple incursions of different subtypes of highly pathogenic avian influenza (HPAI) A/H5NX viruses have caused widely considerable outbreaks in poultry and hundreds of human infections. Extensive reassortment events associated with currently circulating clade 2.3.4.4b of A/H5NX viruses have been widely recorded. Wild migratory birds contribute to the spillover of diverse viruses throughout their migration flyways. During our active surveillance of avian influenza in Egypt, we successfully isolated and fully characterized HPAI A/H5N5 virus of clade 2.3.4.4b that was detected in a healthy purple heron. The Egyptian H5N5 virus is genotypically similar with the same subtype that was detected in the far east of Russia and several European countries. The antigenic analysis showed that the Egyptian H5N5 virus is distinct from HPAI A(H5N8) viruses in Egypt. The virus preferentially binds to avian-like receptors rather than human-like receptors. Our results showed that the virus caused 100% and 60% lethality in chicken and mice respectively. Increasing active surveillance efforts, monitoring the dynamics of emerging AIVs, and risk assessment implementation should be globally applied especially in hot spot regions like Egypt.
Competing Interests: Declaration of competing interest The authors declare no competing interest.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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