Evaluation of hydroxamate-based resins towards a more clinically viable 44 Ti/ 44 Sc radionuclide generator.

Autor: Gajecki L; Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA. Electronic address: lgajecki@bnl.gov., Marino CM; Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA; Chemistry Department, Stony Brook University, Stony Brook, NY, 11794, USA., Cutler CS; Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA., Sanders VA; Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2023 Feb; Vol. 192, pp. 110588. Date of Electronic Publication: 2022 Nov 29.
DOI: 10.1016/j.apradiso.2022.110588
Abstrakt: Several hydroxamate-based resins were synthesized and tested for use in 44 Ti/ 44 Sc generator systems in small scale experiments (740 kBq 44 Ti). The most promising resin was tested further in larger scale generator studies (37 MBq). This resin displayed impressive retention of 44 Ti over several elutions, and high quantities of 44 Sc were obtained in small volumes of dilute HCl eluents. Initial radiolabeling experiments were conducted and demonstrated the possibility of direct radiolabeling of the generator produced 44 Sc with DOTA.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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