Self-Powered Programming of Fibroblasts into Neurons via a Scalable Magnetoelastic Generator Array.

Autor:	Libanori A; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Soto J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Xu J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Song Y; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Zarubova J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Tat T; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Xiao X; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Yue SZ; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, 90095, USA., Jonas SJ; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Children's Discovery and Innovation Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Li S; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Chen J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jazyk:	angličtina
Zdroj:	Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2023 Feb; Vol. 35 (7), pp. e2206933. Date of Electronic Publication: 2022 Dec 20.
DOI:	10.1002/adma.202206933
Abstrakt:	Developing scalable electrical stimulating platforms for cell and tissue engineering applications is limited by external power source dependency, wetting resistance, microscale size requirements, and suitable flexibility. Here, a versatile and scalable platform is developed to enable tunable electrical stimulation for biological applications by harnessing the giant magnetoelastic effect in soft systems, converting gentle air pressure (100-400 kPa) to yield a current of up to 10.5 mA and a voltage of 9.5 mV. The platform can be easily manufactured and scaled up for integration in multiwell magnetoelastic plates via 3D printing. The authors demonstrate that the electrical stimulation generated by this platform enhances the conversion of fibroblasts into neurons up to 2-fold (104%) and subsequent neuronal maturation up to 3-fold (251%). This easily configurable electrical stimulation device has broad applications in high throughput organ-on-a-chip systems, and paves the way for future development of neural engineering, including cellular therapy via implantable self-powered electrical stimulation devices. (© 2022 Wiley-VCH GmbH.)
Databáze:	MEDLINE
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