Rodent peri-implantitis models: a systematic review and meta-analysis of morphological changes.

Autor:	Chew RJJ; Faculty of Dentistry, National University of Singapore, Singapore. dencrjj@nus.edu.sg., Lu JX; Faculty of Dentistry, National University of Singapore, Singapore., Sim YF; Faculty of Dentistry, National University of Singapore, Singapore., Yeo ABK; Faculty of Dentistry, National University of Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Journal of periodontal & implant science [J Periodontal Implant Sci] 2022 Dec; Vol. 52 (6), pp. 479-495. Date of Electronic Publication: 2022 Jun 20.
DOI:	10.5051/jpis.2200900045
Abstrakt:	Purpose: Rodent models have emerged as an alternative to established larger animal models for peri-implantitis research. However, the construct validity of rodent models is controversial due to a lack of consensus regarding their histological, morphological, and biochemical characteristics. This systematic review sought to validate rodent models by characterizing their morphological changes, particularly marginal bone loss (MBL), a hallmark of peri-implantitis. Methods: This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A literature search was performed electronically using MEDLINE (PubMed), and Embase, identifying pre-clinical studies reporting MBL after experimental peri-implantitis induction in rodents. Each study's risk of bias was assessed using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE) risk of bias tool. A meta-analysis was performed for the difference in MBL, comparing healthy implants to those with experimental peri-implantitis. Results: Of the 1,014 unique records retrieved, 23 studies that met the eligibility criteria were included. Peri-implantitis was induced using 4 methods: ligatures, lipopolysaccharide, microbial infection, and titanium particles. Studies presented high to unclear risks of bias. During the osseointegration phase, 11.6% and 6.4%-11.3% of implants inserted in mice and rats, respectively, had failed to osseointegrate. Twelve studies were included in the meta-analysis of the linear MBL measured using micro-computed tomography. Following experimental peri-implantitis, the MBL was estimated to be 0.25 mm (95% confidence interval [CI], 0.14-0.36 mm) in mice and 0.26 mm (95% CI, 0.19-0.34 mm) in rats. The resulting peri-implant MBL was circumferential, consisting of supra- and infrabony components. Conclusions: Experimental peri-implantitis in rodent models results in circumferential MBL, with morphology consistent with the clinical presentation of peri-implantitis. While rodent models are promising, there is still a need to further characterize their healing potentials, standardize experiment protocols, and improve the reporting of results and methodology. Trial Registration: PROSPERO Identifier: CRD42020209776. Competing Interests: No potential conflict of interest relevant to this article was reported. (Copyright © 2022. Korean Academy of Periodontology.)
Databáze:	MEDLINE
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