Bijels as a Fluid Labyrinth for Drugs: The Effect of Nanoparticles on the Release Kinetics of Ethosuximide and Dimethyl Fumarate.

Autor:	Vanoli V; Department of Chemistry, Materials and Chemical Engineering 'G. Natta', Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy., Massobrio G; Department of Chemistry, Materials and Chemical Engineering 'G. Natta', Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy., Pizzetti F; Department of Chemistry, Materials and Chemical Engineering 'G. Natta', Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy., Mele A; Department of Chemistry, Materials and Chemical Engineering 'G. Natta', Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.; CNR Istituto di Chimica del Riconoscimento Molecolare, Via Mancinelli 7, 20131Milan, Italy., Rossi F; Department of Chemistry, Materials and Chemical Engineering 'G. Natta', Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy., Castiglione F; Department of Chemistry, Materials and Chemical Engineering 'G. Natta', Politecnico di Milano, Piazza L. Da Vinci, 32, 20133Milano, Italy.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2022 Nov 16; Vol. 7 (47), pp. 42845-42853. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).
DOI:	10.1021/acsomega.2c04834
Abstrakt:	Bijels (bicontinuous interfacially jammed emulsion gels) raised an increasing interest as biomaterials for controlled drug delivery due to their biphasic nature organized in mesoscopic tortuous domains. Two bijel formulations were prepared and explored as delivery systems for both hydrophilic and lipophilic drugs, ethosuximide and dimethyl fumarate. The two bijel-like structures, based on polymerized ε-caprolactone/water, differ in the stabilizing nanoparticle hydroxyapatite (inorganic) and nanogel-based nanoparticles (organic). Diffusion nuclear magnetic resonance spectroscopy has been used to characterize the bijel structure and the transport behavior of the drug molecules confined within the water/organic interconnected domains. A reduced diffusion coefficient is observed for several concentrations of the drugs and both bijel formulations. Moreover, in vitro release profiles also reveal the effect of the microstructure and drug-nanoparticle interactions. Competing Interests: The authors declare no competing financial interest. (© 2022 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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