Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis.

Autor: García-Abellás P; Department of Pathology Ramón y Cajal Universitary Hospital Madrid Spain., Ferrer Gómez A; Department of Pathology Ramón y Cajal Universitary Hospital Madrid Spain., Bueno Sacristán D; Department of Pathology Ramón y Cajal Universitary Hospital Madrid Spain., Piris Villaespesa M; Department of Hematology Ramón y Cajal Universitary Hospital Madrid Spain., Talavera Yagüe M; Department of Genetics Ramón y Cajal Universitary Hospital Madrid Spain., Reguero Callejas ME; Department of Pathology Ramón y Cajal Universitary Hospital Madrid Spain., García-Cosío M; Head of Hematopathology Department Ramón y Cajal Universitary Hospital; Alcalá University, Madrid, Spain; Instituto Ramon y Cajal de Investigacion Sanitaria, Madrid, Spain; CIBERONC Madrid Spain.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2022 Oct 05; Vol. 3 (4), pp. 1181-1187. Date of Electronic Publication: 2022 Oct 05 (Print Publication: 2022).
DOI: 10.1002/jha2.573
Abstrakt: Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens.
Competing Interests: There is no conflict of interest of any of the authors with the results of this study.
(© 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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