Mycoplasma genitalium and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study).

Autor: De Baetselier I; Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Vuylsteke B; Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium., Cuylaerts V; Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Cuer B; TransVIHMI, Université Montpellier, Institut de Recherche pour le Développement, Inserm, Montpellier, France., Yaya I; TransVIHMI, Université Montpellier, Institut de Recherche pour le Développement, Inserm, Montpellier, France., Mensah E; Espoir Vie Togo, Lomé, Togo., Dah E; Association African Solidarité, Ouagadougou, Burkina Faso., Anoma C; Espace Confiance, Abidjan, Côte d'Ivoire., Koné A; University Center of Clinical Research, University of Sciences, Technics and Technologies of Bamako, Bamako, Mali., Diandé S; Laboratoire National de Référence de Tuberculose, Ouagadougou, Burkina Faso., Dagnra A; Laboratoire des Mycobactéries, Lomé, Togo., Fayé-Ketté H; Institut Pasteur Côte d'Ivoire, Abidjan, Côte d'Ivoire., Yeo A; Institut Pasteur Côte d'Ivoire, Abidjan, Côte d'Ivoire., Smet H; Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Van den Bossche D; Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Keita BD; ARCAD Santé PLUS, Bamako, Mali., Spire B; Sciences économiques et sociales de la santé & traitement de l'information médicale, Aix-Marseille Université, Inserm, Institut de Recherche pour le Développement, Marseille, France., Laurent C; TransVIHMI, Université Montpellier, Institut de Recherche pour le Développement, Inserm, Montpellier, France., Crucitti T; Institut Pasteur de Madagascar, Antanarivo, Madagascar.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2022 Nov 09; Vol. 9 (11), pp. ofac615. Date of Electronic Publication: 2022 Nov 09 (Print Publication: 2022).
DOI: 10.1093/ofid/ofac615
Abstrakt: Background: Antimicrobial resistance to macrolides and fluoroquinolones in Mycoplasma genitalium (MG) among men who have sex with men (MSM) is worryingly high in high-resource countries. Data in Africa are lacking. We aimed to assess the burden of MG including the presence of resistance-associated mutations (RAMs) in MG among MSM using human immunodeficiency virus preexposure prophylaxis in Burkina Faso, Côte d'Ivoire, Mali, and Togo.
Methods: MSM were included in a prospective cohort study (2017-2021). Molecular detection of MG in urine, anorectal, and pharyngeal samples was performed at baseline and after 6 and 12 months. Detection of RAMs to macrolides and fluoroquinolones was performed by sequencing the 23S ribosomal RNA, parC , and gyrA genes. A sample was found to be possibly resistant to fluoroquinolones if alterations were found in ParC position 83/87.
Results: Of 598 participants, 173 (28.9%) were positive at least once for MG and global point-prevalence was 19.4%. Interestingly, 238 of 250 (95.2%) infections were asymptomatic and 72 of 138 MG infections with follow-up data (52.2%) cleared during the study. Only 1 macrolide RAM was found (0.6%). Prevalence of fluoroquinolones RAMs was 11.3% overall, ranging from 2.4% in Burkina Faso to 17.5% in Mali.
Conclusions: Although MG was highly prevalent in these MSM, macrolide resistance was almost nonexistent. Nevertheless, >10% of the samples were possibly resistant to fluoroquinolones. Heterogeneity in the prevalence of fluoroquinolone RAMs between countries may be explained by different antimicrobial consumption in humans and animals.
Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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