Human milk nutritional composition across lactational stages in Central Africa.

Autor:	Moya-Alvarez V; Unité de Pathogénie Microbienne Moléculaire, INSERM U1202, Department of Cell Biology and Infection, Institut Pasteur, Paris, France.; Epidemiology of Emergent Diseases Unit, Global Health Department, Institut Pasteur, Paris, France., Eussen SRBM; Human Milk Research and Analytical Science, Danone Nutricia Research, Utrecht, Netherlands., Mank M; Human Milk Research and Analytical Science, Danone Nutricia Research, Utrecht, Netherlands., Koyembi JJ; Unité d'Epidémiologie, Institut Pasteur de Bangui, Bangui, Central African Republic., Nyasenu YT; Laboratoire d'Analyses Médicales, Institut Pasteur de Bangui, Bangui, Central African Republic.; Laboratoire de Biologie Moléculaire et d'Immunologie, Université de Lomé, Lomé, Togo., Ngaya G; Laboratoire de Biologie Moléculaire et d'Immunologie, Université de Lomé, Lomé, Togo., Mad-Bondo D; Direction du Service de Santé de la Gendarmerie, Sis Camp Henri Izamo, Bangui, Central African Republic., Kongoma JB; Direction du Service de Santé de la Gendarmerie, Sis Camp Henri Izamo, Bangui, Central African Republic., Stahl B; Human Milk Research and Analytical Science, Danone Nutricia Research, Utrecht, Netherlands.; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands., Sansonetti PJ; Unité de Pathogénie Microbienne Moléculaire, INSERM U1202, Department of Cell Biology and Infection, Institut Pasteur, Paris, France.; Chaire de Microbiologie et Maladies Infectieuses, Collège de France, Paris, France., Bourdet-Sicard R; Health and Nutrition Africa, Danone Nutricia Research, Palaiseau, France.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2022 Nov 16; Vol. 9, pp. 1033005. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).
DOI:	10.3389/fnut.2022.1033005
Abstrakt:	The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from African women is scarce. This is of special concern, as we have no reference data from HM composition in the context of food insecurity in Africa. Furthermore, data on the evolution of HM across lactational stages in this setting lack as well. In the MITICA study, we conducted a cohort study among 48 Central-African women and their 50 infants to analyze the emergence of gut dysbiosis in infants and describe the mother-infant transmission of microbiota between birth and 6 months of age. In this context, we assessed nutritional components in HM of 48 lactating women in Central Africa through five sampling times from week 1 after birth until week 25. Unexpectedly, HM-type III (Secretor + and Lewis genes -) was predominant in HM from Central African women, and some nutrients differed significantly among HM-types. While lactose concentration increased across lactation periods, fatty acid concentration did not vary significantly. The overall median level of 16 detected individual human milk oligosaccharides (HMOs; core structures as well as fucosylated and sialylated ones) decreased from 7.3 g/l at week 1 to 3.5 g/l at week 25. The median levels of total amino acids in HM dropped from 12.8 mg/ml at week 1 to 7.4 mg/ml at week 25. In contrast, specific free amino acids increased between months 1 and 3 of lactation, e.g., free glutamic acid, glutamine, aspartic acid, and serine. In conclusion, HM-type distribution and certain nutrients differed from Western mother HM. Competing Interests: SE, MM, BS, and RB-S were Danone Nutricia Research employees. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Moya-Alvarez, Eussen, Mank, Koyembi, Nyasenu, Ngaya, Mad-Bondo, Kongoma, Stahl, Sansonetti and Bourdet-Sicard.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu