Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol.

Autor: Coêlho ML; Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil., Islam MT; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh., Laylson da Silva Oliveira G; Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil., Oliveira Barros de Alencar MV; Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil., Victor de Oliveira Santos J; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil., Campinho Dos Reis A; Integral Diferencial College (FACID-DEVRY), Teresina, Piaui, Brazil., Oliveira Ferreira da Mata AM; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil., Correia Jardim Paz MF; Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil., Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador, Iran., Amélia de Carvalho Melo-Cavalcante A; Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.; Post-Graduation Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Brazil.
Jazyk: angličtina
Zdroj: Advances in pharmacological and pharmaceutical sciences [Adv Pharmacol Pharm Sci] 2022 Nov 23; Vol. 2022, pp. 8002766. Date of Electronic Publication: 2022 Nov 23 (Print Publication: 2022).
DOI: 10.1155/2022/8002766
Abstrakt: The therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic, cytotoxic, and oxidant/antioxidant effects of these compounds by several in vitro (DPPH and ABTS radical scavenging, and ferric reducing potential), ex vivo (hemolysis), and in vivo ( Artemia Salina and Saccharomyces cerevisiae ) assays. Results suggest that estragole and 3,7-dimethyl-1-octanol at 31.25-500  μ g/mL did not exhibit significant cytotoxic effects in the A. Salina and hemolysis tests. Nerol showed significant cytotoxic effects on these test systems at all test concentrations. The monoterpenes showed radical (ABTS •+ and DPPH • ) scavenging capacities in a concentration-dependent manner in vitro tests. However, they did not oxidize the genetic material of S. cerevisiae (SODWT, Sod1Δ, Sod2Δ, Sod1/Sod2Δ, Cat1Δ, and Cat1Δ/Sod1Δ) lines. Among the three monoterpenes, nerol may be a good candidate for antioxidant and anti-tumor therapies.
Competing Interests: There are no conflicts of interest.
(Copyright © 2022 Mayara Ladeira Coêlho et al.)
Databáze: MEDLINE
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