Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI.

Autor:	Sadaghiani S; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Trotman W; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lim SA; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chung E; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ittyerah R; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ravikumar S; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Khandelwal P; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Prabhakaran K; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lavery ML; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ohm DT; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Gabrielyan M; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Das SR; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Schuck T; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Capp N; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Peterson CS; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Migdal E; College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Artacho-Pérula E; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Jiménez MDMA; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Rabal MDPM; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Sánchez SC; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Prieto CR; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Parada MC; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Insausti R; Human Neuroanatomy Laboratory, Neuromax CSIC Associated Unit, University of Castilla-La Mancha, Albacete, Spain., Robinson JL; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., McMillan C; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Grossman M; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Detre JA; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Xie SX; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Tisdall MD; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wisse LEM; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Diagnostic Radiology, Lund University, Lund, Sweden., Irwin DJ; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wolk DA; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Yushkevich PA; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jun; Vol. 19 (6), pp. 2355-2364. Date of Electronic Publication: 2022 Dec 04.
DOI:	10.1002/alz.12884
Abstrakt:	Introduction: Neurodegenerative disorders are associated with different pathologies that often co-occur but cannot be measured specifically with in vivo methods. Methods: Thirty-three brain hemispheres from donors with an Alzheimer's disease (AD) spectrum diagnosis underwent T2-weighted magnetic resonance imaging (MRI). Gray matter thickness was paired with histopathology from the closest anatomic region in the contralateral hemisphere. Results: Partial Spearman correlation of phosphorylated tau and cortical thickness with TAR DNA-binding protein 43 (TDP-43) and α-synuclein scores, age, sex, and postmortem interval as covariates showed significant relationships in entorhinal and primary visual cortices, temporal pole, and insular and posterior cingulate gyri. Linear models including Braak stages, TDP-43 and α-synuclein scores, age, sex, and postmortem interval showed significant correlation between Braak stage and thickness in the parahippocampal gyrus, entorhinal cortex, and Broadman area 35. Conclusion: We demonstrated an association of measures of AD pathology with tissue loss in several AD regions despite a limited range of pathology in these cases. Highlights: Neurodegenerative disorders are associated with co-occurring pathologies that cannot be measured specifically with in vivo methods. Identification of the topographic patterns of these pathologies in structural magnetic resonance imaging (MRI) may provide probabilistic biomarkers. We demonstrated the correlation of the specific patterns of tissue loss from ex vivo brain MRI with underlying pathologies detected in postmortem brain hemispheres in patients with Alzheimer's disease (AD) spectrum disorders. The results provide insight into the interpretation of in vivo structural MRI studies in patients with AD spectrum disorders. (© 2022 the Alzheimer's Association.)
Databáze:	MEDLINE
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