Disorders of sex development: Challenges in a low-resource country.

Autor: Ehua AM; Department of Pediatric Surgery Treichville Teaching Hospital Abidjan, Côte d'Ivoire 01 BP V 03 Abidjan 01. Electronic address: ehuamanuela15@gmail.com., Moulot MO; Department of Pediatric Surgery Treichville Teaching Hospital Abidjan, Côte d'Ivoire 01 BP V 03 Abidjan 01., Agbara KS; Department of Pediatric Surgery Treichville Teaching Hospital Abidjan, Côte d'Ivoire 01 BP V 03 Abidjan 01., Enache T; Clinical Emergency Hospital for Children, Grigore Alexandrescu Bucharest, Romania., Bankole SR; Department of Pediatric Surgery Treichville Teaching Hospital Abidjan, Côte d'Ivoire 01 BP V 03 Abidjan 01.
Jazyk: angličtina
Zdroj: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2023 Jan; Vol. 30 (1), pp. 10-13. Date of Electronic Publication: 2022 Nov 30.
DOI: 10.1016/j.arcped.2022.09.002
Abstrakt: Aim: We aimed to identify the challenges in the management of sexual development abnormalities in a low-resource country.
Methods: The study was retrospective from January 2000 to December 2017 based on patient records from two pediatric surgery departments. Epidemiological, clinical, paraclinical, treatment, and outcome data were studied.
Results: We collected data on 13 patients (average age = 7.95 years). The sex of rearing was as follows: three females (23%), 10 males (77%). Atypical genitalia other than hypospadias represented the reason for consultation in 92% of the cases. We could not find complete hormonal analyses; testosterone levels were studied in 69.23% of cases. We found the following disorders of sexual development (DSD): four patients with 46,XX karyotype (30.77%), eight patients with 46,XY karyotype (61.53%), and one patient with 46,XX/XY karyotype. Four patients had medical treatment only, four had surgical treatment only, and one patient had medical and surgical treatment. The medical treatment comprised topical administration of androgen. The surgical treatment consisted of feminizing genitoplasty for one patient and masculinizing genital surgeries for two patients. Six of the 13 patients were lost to follow-up.
Conclusion: The socioeconomic difficulties of the population and the lack of access to basic diagnostic and paraclinical methods, coupled with the negative cultural representations of the pathology, constitute the challenges in the management of DSD in our practice.
Competing Interests: Disclosure of Competing Interest The authors declare that they have no competing interest.
(Copyright © 2022 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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