The impact of the secondary infections in ICU patients affected by COVID-19 during three different phases of the SARS-CoV-2 pandemic.

Autor: Murgia F; Department of Biomedical Sciences, Clinical Metabolomics Unit, University of Cagliari, Cagliari, Italy., Fiamma M; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Serra S; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Marras G; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Argiolas R; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Mattana C; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Mattu MG; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Garau MC; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Doneddu S; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Olla S; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Cocco E; Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.; Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, ASSL Cagliari, Cagliari, Italy., Lorefice L; Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, ASSL Cagliari, Cagliari, Italy., Muntoni S; Department of Biomedical Sciences, Clinical Metabolomics Unit, University of Cagliari, Cagliari, Italy., Paffi P; Intensive Care Unit, 'San Francesco' Hospital, Nuoro, Italy., Porru S; Intensive Care Unit, 'San Francesco' Hospital, Nuoro, Italy., Abis M; Intensive Care Unit, 'San Francesco' Hospital, Nuoro, Italy., Bellizzi S; Amman, Jordan., Pani A; Nephrology, Dialysis and Transplantation, University of Cagliari, Cagliari, Italy., Angioi A; Nephrology, Dialysis and Transplantation, University of Cagliari, Cagliari, Italy., Simbula G; Department of Biomedical Sciences, Oncology and Molecular Pathology Unit, University of Cagliari, Cagliari, Italy., Mussap M; Department of Surgical Sciences, University of Cagliari, Cagliari, Italy., Massidda O; Department of Cellular, Computational and Integrative Biology, Center of Medical Sciences (CISMed), University of Trento, Trento, Italy., Carta F; Clinical-Chemical Analysis and Microbiology Laboratory, 'San Francesco' Hospital, Nuoro, Italy., Atzori L; Department of Biomedical Sciences, Clinical Metabolomics Unit, University of Cagliari, Strada Interna Policlinico Universitario, 09042, Monserrato, CA, Italy. latzori@unica.it.
Jazyk: angličtina
Zdroj: Clinical and experimental medicine [Clin Exp Med] 2023 Aug; Vol. 23 (4), pp. 1251-1263. Date of Electronic Publication: 2022 Dec 02.
DOI: 10.1007/s10238-022-00959-1
Abstrakt: Microbial secondary infections can contribute to an increase in the risk of mortality in COVID-19 patients, particularly in case of severe diseases. In this study, we collected and evaluated the clinical, laboratory and microbiological data of COVID-19 critical ill patients requiring intensive care (ICU) to evaluate the significance and the prognostic value of these parameters. One hundred seventy-eight ICU patients with severe COVID-19, hospitalized at the S. Francesco Hospital of Nuoro (Italy) in the period from March 2020 to May 2021, were enrolled in this study. Clinical data and microbiological results were collected. Blood chemistry parameters, relative to three different time points, were analyzed through multivariate and univariate statistical approaches. Seventy-four percent of the ICU COVID-19 patients had a negative outcome, while 26% had a favorable prognosis. A correlation between the laboratory parameters and days of hospitalization of the patients was observed with significant differences between the two groups. Moreover, Staphylococcus aureus, Enterococcus faecalis, Candida spp, Pseudomonas aeruginosa and Klebsiella pneumoniae were the most frequently isolated microorganisms from all clinical specimens. Secondary infections play an important role in the clinical outcome. The analysis of the blood chemistry tests was found useful in monitoring the progression of COVID-19.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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