Crystalline silica exposure in patients with rheumatoid arthritis and systemic sclerosis: a nationwide cross-sectional survey.

Autor:	Cavalin C; IRISSO, UMR CNRS-INRAE 7170-1427, Paris-Dauphine University, PSL, Paris, France.; Laboratory for Interdisciplinary Evaluation of Public Policies (LIEPP), Sciences Po,Paris, France.; Centre d'études de l'emploi et du travail (CEET, CNAM), Noisy-le-Grand, France., Lescoat A; Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France.; Inserm, EHESP, Irset (Institute for Research in Health, Environment and Work) - UMR_S 1085, Rue du Thabor, France., Sigaux J; Inserm U1125, Sorbonne Paris Nord University, Li2P, Bobigny, France.; Rheumatology Department, Assistance Publique-Hôpitaux de Paris, GH HUPSSD, Bobigny, France., Macchi O; Investigation Department of the International Observatory of Prisons (OIP), Paris, France.; Centre for the Study of Social Movements (CEMS), École des Hautes Études en Sciences Sociales (EHESS), Paris, France., Ballerie A; Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France.; Inserm, EHESP, Irset (Institute for Research in Health, Environment and Work) - UMR_S 1085, Rue du Thabor, France., Catinon M; MINAPATH Développement, Villeurbanne Cedex, France., Vincent M; MINAPATH Développement, Villeurbanne Cedex, France., Semerano L; Inserm U1125, Sorbonne Paris Nord University, Li2P, Bobigny, France.; Rheumatology Department, Assistance Publique-Hôpitaux de Paris, GH HUPSSD, Bobigny, France., Boissier MC; Inserm U1125, Sorbonne Paris Nord University, Li2P, Bobigny, France.; Rheumatology Department, Assistance Publique-Hôpitaux de Paris, GH HUPSSD, Bobigny, France., Rosental PA; Centre for History, Sciences Po (CHSP), Paris Cedex 07, France.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Aug 01; Vol. 62 (8), pp. 2707-2715.
DOI:	10.1093/rheumatology/keac675
Abstrakt:	Objectives: Develop and validate a thorough exposure questionnaire to comprehensively explore crystalline silica (SiO2) exposure in the general population (gender-specific, occupational and non-occupational) and in patients with autoimmune diseases (rheumatoid arthritis (RA), systemic sclerosis (SSc)). Methods: Lifetime exposures to SiO2 in occupational and non-occupational settings were assessed using a thorough exposure questionnaire. The questionnaire was applied to a general population panel (n = 2911) sampled from the French rolling census, and to unselected patients with SSc (n = 100) and RA (n = 97). Global (GES), occupational (OES) and non-occupational (NOES) exposure scores were assessed in SSc and RA patients, and compared with up to four controls from the general population, matched by age group, sex and tobacco consumption. Results: Patients had higher GES than their matched controls (SSc: P = 0.001; RA: P < 0.0001) due to higher OES (P < 0.0001 for SSc and RA). Men had higher GES than women (SSc: P < 0.0001; RA: P = 0.002) due to higher OES (P < 0.0001 for SSc and RA). The NOES did not differ between men and women. In SSc patients: Men had higher GES than controls (P < 0.0001). Men and women with SSc had higher OES than controls (P < 0.0001). In RA patients: GES and OES were higher in both men (P = 0.00521; P < 0.0001) and women (P < 0.0001; P < 0.0001) than in their respective controls. Women had higher NOES than controls (P = 0.045). Conclusion: The lifetime SiO2 exposure gap between RA and SSc patients and controls was substantially due to occupational exposure. In both diseases, men had higher exposure scores than women. (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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