rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality.

Autor: Beheshti Shirazi SS; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran., Sakhaee F; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran., Sotoodehnejadnematalahi F; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran., Zamani MS; Immunoregulation Research Center, Shahed University, Tehran, Iran., Ahmadi I; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran., Anvari E; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran., Fateh A; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2022 Nov 22; Vol. 2022, pp. 7841969. Date of Electronic Publication: 2022 Nov 22 (Print Publication: 2022).
DOI: 10.1155/2022/7841969
Abstrakt: The protease produced by the transmembrane serine protease 2 ( TMPRSS2 ) gene enhances viral infections and has been linked to severe acute respiratory syndrome coronavirus 2 pathogenesis. Therefore, this study evaluated the association between TMPRSS2 and coronavirus disease 2019 (COVID-19) mortality. TMPRSS2 rs12329760 polymorphism was genotyped using the tetraprimer amplification refractory mutation system-polymerase chain reaction method in 592 dead and 693 improved patients. In the current study, the frequency of TMPRSS2 rs12329760 CC than TT genotypes was significantly lower in improved patients than in dead patients. According to the findings of the multivariate logistic regression test, higher levels of mean age, creatinine, erythrocyte sedimentation rate, C-reactive protein, aspartate aminotransferase, lower levels of 25-hydroxyvitamin D, uric acid, and real-time PCR Ct values and TMPRSS2 rs12329760 CC genotype were observed to be associated with increased COVID-19 mortality rates. In conclusion, the TMPRSS2 rs12329760 CC genotype was a polymorphism linked to a significantly higher incidence of severe COVID-19. Further studies are required to corroborate the obtained findings.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Saeedeh Sadat Beheshti Shirazi et al.)
Databáze: MEDLINE
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