| Autor: |
Phunpee S; Center of Excellence in Bioresources to Advanced Materials (B2A-CE), The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand., Ruktanonchai UR; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12120, Thailand., Chirachanchai S; Center of Excellence in Bioresources to Advanced Materials (B2A-CE), The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomacromolecules [Biomacromolecules] 2022 Dec 12; Vol. 23 (12), pp. 5361-5372. Date of Electronic Publication: 2022 Dec 01. |
| DOI: |
10.1021/acs.biomac.2c01226 |
| Abstrakt: |
Multistimuli-responsive polymers are important for controlled release. Owing to the fact that these polymers are derived from vinyl-based monomers, their decoration with other molecules is limited. Polysaccharides, especially chitosan (CS) and hyaluronic acid (HA), are pH-responsive biopolymers, whose chemical structures contain reactive functional groups for feasible chemical modifications to obtain add-on functions. The present work demonstrates the introduction of polymers with upper critical solution temperature (UCST) and lower critical solution temperature (LCST) performances onto CS and HA, respectively. By simply varying the mole ratio between the CS-containing UCST polymer and the HA-containing LCST polymer along with adjusting the pH, a polymer system with a UCST-LCST-pH multiresponsive window can be obtained. This multiresponsive window enables us to control the encapsulation and release with repeatability as evidenced from a model study on lysozyme. The present work, for the first time, shows a simple approach to obtain multiresponsive biodegradable polymers through the formation of a single polymer complex to tailor a specific multiresponsive window. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
