The Role of Reduced Glutathione on the Activity of Adenosine Deaminase, Antioxidative System, and Aluminum and Zinc Levels in Experimental Aluminum Toxicity.

Autor: Atakisi O; Department of Chemistry, Faculty of Science and Letter, Kafkas University, Kars, Turkey. onuratakisi@hotmail.com., Dalginli KY; Department of Chemistry and Chemical Processing Technologies Kars Vocational School, Kafkas University, Kars, Turkey., Gulmez C; Department of Pharmacy Services, Tuzluca Vocational School, Igdir University, Igdir, Turkey., Kalacay D; Department of Chemistry and Chemical Processing Technologies Kars Vocational School, Kafkas University, Kars, Turkey., Atakisi E; Faculty of Veterinary Medicine Department of Biochemistry, Kafkas University, Kars, Turkey., Zhumabaeva TT; Department of Biology Medical Institute, Osh State University, Osh, Kyrgyzstan., Aşkar TK; Department of Dietetics and Nutrition, Faculty of Health Sciences, Çankırı Karatekin University, Çankırı, Turkey., Demirdogen RE; Deptartments of Chemistry Faculty of Science, Çankırı Karatekin University, Çankırı, Turkey.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2023 Sep; Vol. 201 (9), pp. 4429-4436. Date of Electronic Publication: 2022 Dec 02.
DOI: 10.1007/s12011-022-03503-0
Abstrakt: Aluminum (Al) is one of the most abundant element in the world. But aluminum exposure and accumulation causes serious diseases, related with free radicals. Reduced glutathione (GSH) is a tripeptide with intracellular antioxidant effects. This study aimed to investigate the role of GSH on adenosine deaminase (ADA), antioxidant system, and aluminum and zinc (Zn) levels in acute aluminum toxicity. In this study, Sprague-Dawley rats (n = 32) were used. The rats were divided into four equal groups (n = 8). Group I received 0.5 mL intraperitoneal injection of 0.9% saline solution (NaCI), Group II received single-dose AlCI 3 , Group III was given GSH for seven days, and Group IV was given AlCI 3 single dose, and at the same time, 100 mg/kg GSH was given for seven days. At the end of the trial, blood samples were collected by cardiac puncture. Serum total antioxidant status (TAS) and Zn levels were lower in the aluminum-administered group than the control group. In contrast, plasma total oxidant status (TOS) and aluminum concentrations and ADA activity were found higher in the aluminum-administered group than in the control group. Unlike the other groups, group GSH administrated with aluminum was similar to the control group. As a result, GSH administration has a regulatory effect on ADA activity, antioxidant system, and Zn levels in experimental aluminum toxicity. In addition, GSH may reduce the oxidant capacity increased by Al administration and may have a tolerant role on the accumulated serum Al levels. But long-term experimental Al toxicity studies are needed to reach a firm conclusion.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: