Metabolomics in Cell Biology.
| Autor: | Eraslan Z; Department of Dermatology, Weill Cornell Medicine, New York, NY, USA., Cascante M; Department of Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain.; Institute of Biomedicine of University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.; CIBER of Hepatic and Digestive Diseases (CIBEREHD), Institute of Health Carlos III (ISCIII), Madrid, Spain., Günther UL; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany. Ulrich.guenther@uni-luebeck.de. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Handbook of experimental pharmacology [Handb Exp Pharmacol] 2023; Vol. 277, pp. 181-207. |
| DOI: | 10.1007/164_2022_619 |
| Abstrakt: | Metabolomics has long been used in a biomedical context. The most typical samples are body fluids in which small molecules can be detected and quantified using technologies such as Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS). Many studies, in particular in the wider field of cancer research, are based on cellular models. Different cancer cells can have vastly different ways of regulating metabolism and responses to drug treatments depend on specific metabolic mechanisms which are often cell type specific. This has led to a series of publications using metabolomics to study metabolic mechanisms. Cell-based metabolomics has specific requirements and allows for interesting approaches where metabolism is followed in real-time. Here applications of metabolomics in cell biology have been reviewed, providing insight into specific technologies used and showing exemplary case studies with an emphasis towards applications which help to understand drug mechanisms. (© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|