Fast evaluation of the safety of chemical reactions using cytotoxicity potentials and bio-Strips.

Autor: Egorova KS; Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia. Electronic address: egorova-ks@ioc.ac.ru., Posvyatenko AV; Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russian Federation, Moscow, 117198, Russia., Galushko AS; Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia., Ananikov VP; Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia. Electronic address: val@ioc.ac.ru.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2023 Feb; Vol. 313, pp. 137378. Date of Electronic Publication: 2022 Nov 28.
DOI: 10.1016/j.chemosphere.2022.137378
Abstrakt: We introduce new quantitative environmental metrics - "cytotoxicity potentials" - which can be used for the preliminary evaluation of the safety of chemical reactions from the viewpoint of the cytotoxicity of their components. We also elaborate the concept of bio-Profiles to be employed for fast estimation of the potential environmental dangers of chemical processes by (1) including the common cytotoxicity scale for all routes of synthesis of a particular product and (2) proposing a novel, more compact representation of the bio-Profiles themselves in the form of bio-Strips. These improvements allow direct comparisons of various synthetic routes for a particular target product, thus providing faster assessment of the reactions in question from the viewpoint of their "overall cytotoxicity". The advantages of these developments are illustrated by 36 routes of synthesizing 1,1'-biphenyl and 72 routes of synthesizing 4-methoxy-1,1'-biphenyl. The effect of incomplete conversion on bio-Strips and their metrics is also discussed. In addition, we address the impact of the selection of a particular cell line on the evaluation of the reaction safety by comparing the results obtained in three cell lines of various origins.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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