Co-ultramicronized palmitoylethanolamide/luteolin normalizes GABA B -ergic activity and cortical plasticity in long COVID-19 syndrome.

Autor: Versace V; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy. Electronic address: viviana.versace@sabes.it., Ortelli P; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Dezi S; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Ferrazzoli D; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Alibardi A; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Bonini I; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Engl M; Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Maestri R; Department of Biomedical Engineering, Scientific Institute of Montescano - IRCCS, Istituti Clinici Scientifici Maugeri, Pavia, Italy., Assogna M; Experimental Neuropsychophysiology Lab, Santa Lucia Foundation IRCCS, Rome, Italy., Ajello V; Department of Cardiac Anesthesia, Tor Vergata University Hospital, Rome, Italy., Pucks-Faes E; Department of Neurology, Hochzirl Hospital, Zirl, Austria., Saltuari L; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Sebastianelli L; Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Italy., Kofler M; Department of Neurology, Hochzirl Hospital, Zirl, Austria., Koch G; Experimental Neuropsychophysiology Lab, Santa Lucia Foundation IRCCS, Rome, Italy; Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2023 Jan; Vol. 145, pp. 81-88. Date of Electronic Publication: 2022 Nov 11.
DOI: 10.1016/j.clinph.2022.10.017
Abstrakt: Objective: Transcranial magnetic stimulation (TMS) studies showed that patients with cognitive dysfunction and fatigue after COVID-19 exhibit impaired cortical GABA B- ergic activity, as revealed by reduced long-interval intracortical inhibition (LICI). Aim of this study was to test the effects of co-ultramicronized palmitoylethanolamide/luteolin (PEA-LUT), an endocannabinoid-like mediator able to enhance GABA-ergic transmission and to reduce neuroinflammation, on LICI.
Methods: Thirty-nine patients (26 females, mean age 49.9 ± 11.4 years, mean time from infection 296.7 ± 112.3 days) suffering from persistent cognitive difficulties and fatigue after mild COVID-19 were randomly assigned to receive either PEA-LUT 700 mg + 70 mg or PLACEBO, administered orally bid for eight weeks. The day before (PRE) and at the end of the treatment (POST), they underwent TMS protocols to assess LICI. We further evaluate short-latency afferent inhibition (SAI) and long-term potentiation (LTP)-like cortical plasticity.
Results: Patients treated with PEA-LUT but not with PLACEBO showed a significant increase of LICI and LTP-like cortical plasticity. SAI remained unaffected.
Conclusions: Eight weeks of treatment with PEA-LUT restore GABA B activity and cortical plasticity in long Covid patients.
Significance: This study confirms altered physiology of the motor cortex in long COVID-19 syndrome and indicates PEA-LUT as a candidate for the treatment of this post-viral condition.
(Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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