Online Databases of Genome Editing in Cardiovascular and Metabolic Diseases.

Autor:	Carrillo-Rodriguez P; Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain., Martinez-Lopez J; Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain., Gómez-Hernández L; Department of Biochemistry and Molecular Biology III and Immunology, University of Granada, Granada, Spain., Boraita-Morales L; Instituto de Parasitología y Biomedicina 'López-Neyra'-CSIC, University of Granada, Granada, Spain., Uceda-Molina M; Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain., Cuenca-Bermejo I; Instituto de Investigación Biosanitaria IBS, Complejo Hospitalario Universitario de Granada, Granada, Spain., Valencia-Aguirre JP; GENYO, Centre for Genomics and Oncological Research-Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain., Mora-López M; Department of Biochemistry and Molecular Biology III and Immunology, University of Granada, Granada, Spain., Plaza-Diaz J; Instituto de Investigación Biosanitaria IBS, Complejo Hospitalario Universitario de Granada, Granada, Spain. jrplaza@ugr.es.; Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. jrplaza@ugr.es.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. jrplaza@ugr.es.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2023; Vol. 1396, pp. 19-33.
DOI:	10.1007/978-981-19-5642-3_2
Abstrakt:	Metabolic and cardiovascular diseases are world-concerning pathologies that affect an important percentage of the population. Nowadays, advances in the genetic background of these diseases allow new approaches to models and therapies, as well as different gene edition trials. Furthermore, technological improvements in gene editing go along with the development of new online and biocomputational tools that provide us alternative ways to explore pathologies. In this chapter, historical gene editing methods are discussed but focusing on CRISPR-Cas system in detail and also online resources available to perform these types of experiments. Here, the different strategies for gene editing and their online tools are gathered, putting the light on its application in the study and treatment of cardiovascular and metabolic diseases. (© 2023. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.)
Databáze:	MEDLINE
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