Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity.

Autor: Iwabuchi SJ; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK., Drabek MM; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK., Cottam WJ; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK., Tadjibaev A; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK., Mohammadi-Nejad AR; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK., Sotiropoulos S; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK., Fernandes GS; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK.; Centre for Sports, Exercise and Osteoarthritis Research Versus Arthritis, University of Nottingham, Nottingham, UK., Valdes AM; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK., Zhang W; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK., Doherty M; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK., Walsh DA; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK., Auer DP; Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2023 Jan; Vol. 57 (2), pp. 373-387. Date of Electronic Publication: 2022 Dec 16.
DOI: 10.1111/ejn.15880
Abstrakt: The reciprocal interaction between pain and negative affect is acknowledged but pain-related alterations in brain circuits involved in this interaction, such as the mediodorsal thalamus (MDThal), still require a better understanding. We sought to investigate the relationship between MDThal circuitry, negative affect and pain severity in chronic musculoskeletal pain. For these analyses, participants with chronic knee pain (CKP, n = 74) and without (n = 36) completed magnetic resonance imaging scans and questionnaires. Seed-based MDThal functional connectivity (FC) was compared between groups. Within CKP group, we assessed the interdependence of MDThal FC with negative affect. Finally, post hoc moderation analysis explored whether burden of pain influences affect-related MDThal FC. The CKP group showed altered MDThal FC to hippocampus, ventromedial prefrontal cortex and subgenual anterior cingulate. Furthermore, in CKP group, MDThal connectivity correlated significantly with negative affect in several brain regions, most notably the medial prefrontal cortex, and this association was stronger with increasing pain burden and absent in pain-free controls. In conclusion, we demonstrate mediodorsal thalamo-cortical dysconnectivity in chronic pain with areas linked to mood disorders and associations of MDThal FC with negative affect. Moreover, burden of pain seems to enhance affect sensitivity of MDThal FC. These findings suggest mediodorsal thalamic network changes as possible drivers of the detrimental interplay between chronic pain and negative affect.
(© 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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