Platelet Rich Fibrin Membrane Grafting After Laser Excision for Oral Mucosal Lesions.

Autor: Tewari NK; Department of Oral and Maxillofacial Surgery, NMCH, Patna, India., Kumar V; Department of ENT, PMCH, Ashok Rajpath, Patna, 800004 India., Choubey N; Department of Biochemistry, NMCH, Patna, India., Tiwari S; Kiran Dental and Maxillofacial Surgery Centre Patna, Patna, India.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2022 Oct; Vol. 74 (Suppl 2), pp. 2506-2512. Date of Electronic Publication: 2020 Nov 03.
DOI: 10.1007/s12070-020-02225-w
Abstrakt: Platelet rich fibrin (PRF) is a novel surgical biomaterial which has shown immense healing and regenerative potential with diverse clinical applications. Surgical excision is a routinely employed treatment modality for mucosal oral lesions with or without grafting or repair of the base of the wound. We proposed a hypothesis that covering of the base of excised lesion with this platelet rich fibrin membrane can accelerate the rate of physiological healing process and regeneration. To evaluate the role, efficacy, advantages and adverse effects if any, of placement of PRF membrane grafts over surgical excision sites of oral mucosal lesions. Platelet rich fibrin membrane graft was prepared as per recommendation and established protocols. Patients were selected for surgical excision of localized, superficial oral mucosal lesions after meticulous clinical and radiological considerations and informed consent was taken. After laser excision with safe margins, the base of wound was covered with PRF membrane graft, stitched in place by 3-0 vicryl sutures. The operated site was clinically evaluated at regular intervals and a healing score was calculated and statistically tabulated on the basis of various parameters of healing. A total of 34 patients were included in the study with a male preponderance (21 males and 13 females). Satisfactory and clinically acceptable wound healing was observed in most of the patient with minimal morbidities. Surgical site demonstrated good healing score and clinically complete healing with good epithelialisation was achieved in all patients. Platelet rich fibrin membrane is an effective grafting biomaterial after excision of oral mucosal lesions as it enhances the rate of healing with minimal complications. We recommend further multicentre studies with higher sample size to explore its utility and clinical applications in different avenues of oral and head neck surgery.
Competing Interests: Conflict of interestAuthors declare that they have no conflict of interest.
(© Association of Otolaryngologists of India 2020.)
Databáze: MEDLINE
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