Acute submaximal exercise does not impact aspects of cognition and BDNF in people with spinal cord injury: A pilot study.

Autor: Nhan K; Brain Exercise Enhancement Laboratory, Department of Kinesiology, McMaster University, Hamilton, ON, Canada., Todd KR; School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada., Jackson GS; School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada., Van der Scheer JW; The Healthcare Improvement Studies (THIS) Institute, University of Cambridge, Cambridge, United Kingdom., Dix GU; School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada., Martin Ginis KA; School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, BC, Canada.; Centre for Chronic Disease Prevention and Management, University of British Columbia, Kelowna, BC, Canada., Little JP; School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada., Walsh JJ; Brain Exercise Enhancement Laboratory, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.; School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.
Jazyk: angličtina
Zdroj: Frontiers in rehabilitation sciences [Front Rehabil Sci] 2022 Nov 14; Vol. 3, pp. 983345. Date of Electronic Publication: 2022 Nov 14 (Print Publication: 2022).
DOI: 10.3389/fresc.2022.983345
Abstrakt: Objective: To investigate the effect of acute submaximal exercise, based on the spinal cord injury (SCI) Exercise Guidelines, on cognition and brain-derived neurotrophic factor (BDNF) in people with SCI.
Design: Eight adults (7 males) with traumatic SCI volunteered in this pre-registered pilot study. In randomized order, participants completed submaximal intensity arm cycling (60% of measured peak-power output at 55-60 rpm) for 30 min or time-matched quiet rest (control condition) on separate days. Blood-borne BDNF was measured in serum and plasma at pre-intervention, 0 min and 90 min post-intervention. Cognition was assessed using the Stroop Test and Task-Switching Test on an electronic tablet pre- and 10 min post-intervention.
Results: Submaximal exercise had no effect on plasma [F (2,12)  = 1.09; P  = 0.365; η ² = 0.069] or serum BDNF [F (2,12)  = 0.507; P  = 0.614; η ² = 0.024] at either 0 min or 90 min post-intervention. Similarly, there was no impact of exercise on either Stroop [F (1,7)  = 2.05; P  = 0.195; η ² = 0.065] or Task-Switching performance [F (1,7)  = 0.016; P  = 0.903; η ² < 0.001] compared to the control condition. Interestingly, there was a positive correlation between years since injury and resting levels of both plasma (r = 0.831; P  = 0.011) and serum BDNF (r = 0.799; P  = 0.023). However, there was not relationship between years since injury and the BDNF response to exercise.
Conclusions: Acute guideline-based exercise did not increase BDNF or improve aspects of cognition in persons with SCI. This work establishes a foundation for continued investigations of exercise as a therapeutic approach to promoting brain health among persons with SCI.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(© 2022 Nhan, Todd, Jackson, Van der Scheer, Dix, Martin Ginis, Little and Walsh.)
Databáze: MEDLINE
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