Head and neck small-cell carcinoma: A multicenter study of 39 cases from 10 institutions.

Autor:	Matsuyama H; Department of Otolaryngology, Niigata City General Hospital, Niigata, Japan., Ueki Y; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Okamoto I; Department of Otolaryngology, Head and Neck Surgery, Tokyo Medical University, Nishishinjuku, Japan., Nagao T; Department of Anatomic Pathology, Tokyo Medical University, Nishishinjuku, Japan., Honda K; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Yamazaki K; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Okabe R; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Togashi T; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Shodo R; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Ota H; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Takahashi T; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Omata J; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Yokoyama Y; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Saijo K; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Tanaka R; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Tsukahara K; Department of Otolaryngology, Head and Neck Surgery, Tokyo Medical University, Nishishinjuku, Japan., Kitahara T; Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan., Uemura H; Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan., Yoshimoto S; Department of Head and Neck Surgery, National Cancer Center Hospital, Tsukiji, Japan., Matsumoto F; Department of Head and Neck Surgery, National Cancer Center Hospital, Tsukiji, Japan.; Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Isehara, Japan., Okami K; Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Sapporo, Japan., Sakai A; Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Sapporo, Japan., Takano K; Department of Otolaryngology, Sapporo Medical University School of Medicine, Suita, Japan., Kondo A; Department of Otolaryngology, Sapporo Medical University School of Medicine, Suita, Japan., Inohara H; Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Yokohama, Japan., Eguchi H; Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Yokohama, Japan., Oridate N; Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Sendagi, Japan., Tanabe T; Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Sendagi, Japan., Nakamizo M; Department of Otorhinolaryngology, Nippon Medical School Hospital, Mita, Japan.; Department of Otorhinolaryngology, Tokyo Women's Medical University, Hongo, Japan., Yokoshima K; Department of Otorhinolaryngology, Nippon Medical School Hospital, Mita, Japan.; Department of Head and Neck Surgery, Tochigi Cancer Center, Kawada, Japan., Miura K; Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Utsunomiya, Japan., Kitani Y; Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Utsunomiya, Japan., Horii A; Department of Otolaryngology, Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in surgery [Front Surg] 2022 Nov 14; Vol. 9, pp. 1049116. Date of Electronic Publication: 2022 Nov 14 (Print Publication: 2022).
DOI:	10.3389/fsurg.2022.1049116
Abstrakt:	Objective: Basal information of head and neck small-cell carcinoma (HNSmCC) including epidemiology, primary site, treatment, and prognosis remains sparse due to its rarity. We report here a multicenter retrospective study on the diagnosis, treatment, and outcomes of patients with HNSmCC. Materials and Methods: This study involved 47 patients with HNSmCC from 10 participating institutions. Eight patients were excluded for whom no pathological specimens were available ( n  = 2) and for discrepant central pathological judgements ( n  = 6). The remaining 39 patients were processed for data analysis. Results: As pretreatment examinations, computed tomography (CT) was performed for the brain ( n  = 8), neck ( n  = 39), and chest ( n  = 32), magnetic resonance imaging (MRI) for the brain ( n  = 4) and neck ( n  = 23), positron emission tomography-CT (PET-CT) in 23 patients, bone scintigraphy in 4, neck ultrasonography in 9, and tumor markers in 25. Primary sites were oral cavity ( n  = 1), nasal cavity/paranasal sinuses ( n  = 16), nasopharynx ( n  = 2), oropharynx ( n  = 4), hypopharynx ( n  = 2), larynx ( n  = 6), salivary gland ( n  = 3), thyroid ( n  = 2), and others ( n  = 3). Stages were II/III/IV-A/IV-B/IV-C/Not determined = 3/5/16/6/5/4; stage IV comprised 69%. No patient had brain metastases. First-line treatments were divided into 3 groups: the chemoradiotherapy (CRT) group ( n  = 27), non-CRT group ( n  = 8), and best supportive care group ( n  = 4). The CRT group included concurrent CRT (CCRT) ( n  = 17), chemotherapy (Chemo) followed by radiotherapy (RT) ( n  = 5), and surgery (Surg) followed by CCRT ( n  = 5). The non-CRT group included Surg followed by RT ( n  = 2), Surg followed by Chemo ( n  = 1), RT alone ( n  = 2), and Chemo alone ( n  = 3). The 1-year/2-year overall survival (OS) of all 39 patients was 65.3/53.3%. The 1-year OS of the CRT group (77.6%) was significantly better compared with the non-CRT group (31.3%). There were no significant differences in adverse events between the CCRT group ( n  = 22) and the Chemo without concurrent RT group ( n  = 9). Conclusion: Neck and chest CT, neck MRI, and PET-CT would be necessary and sufficient examinations in the diagnostic set up for HNSmCC. CCRT may be recommended as the first-line treatment. The 1-year/2-year OS was 65.3%/53.3%. This study would provide basal data for a proposing the diagnostic and treatment algorithms for HNSmCC. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2022 Matsuyama, Ueki, Okamoto, Nagao, Honda, Yamazaki, Okabe, Togashi, Shodo, Ota, Takahashi, Omata, Yokoyama, Saijo, Tanaka, Tsukahara, Kitahara, Uemura, Yoshimoto, Matsumoto, Okami, Sakai, Takano, Kondo, Inohara, Eguchi, Oridate, Tanabe, Nakamizo, Yokoshima, Miura, Kitani and Horii.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu