The combination of autism and exceptional cognitive ability is associated with suicidal ideation.

Autor: Casten LG; Department of Psychiatry, University of Iowa, United States; Interdisciplinary Graduate Program in Genetics, University of Iowa, United States; Iowa Neuroscience Institute, University of Iowa, United States., Thomas TR; Department of Psychiatry, University of Iowa, United States; Interdisciplinary Graduate Program in Genetics, University of Iowa, United States; Iowa Neuroscience Institute, University of Iowa, United States., Doobay AF; Belin-Blank Center, University of Iowa, United States; Department of Psychological and Quantitative Foundations, University of Iowa, United States., Foley-Nicpon M; Belin-Blank Center, University of Iowa, United States; Department of Psychological and Quantitative Foundations, University of Iowa, United States., Kramer S; Department of Psychiatry, University of Iowa, United States; Iowa Neuroscience Institute, University of Iowa, United States., Nickl-Jockschat T; Department of Psychiatry, University of Iowa, United States; Iowa Neuroscience Institute, University of Iowa, United States; Department of Neuroscience and Pharmacology, University of Iowa, United States., Abel T; Iowa Neuroscience Institute, University of Iowa, United States; Department of Neuroscience and Pharmacology, University of Iowa, United States., Assouline S; Belin-Blank Center, University of Iowa, United States; Department of Psychological and Quantitative Foundations, University of Iowa, United States., Michaelson JJ; Department of Psychiatry, University of Iowa, United States; Iowa Neuroscience Institute, University of Iowa, United States. Electronic address: jacob-michaelson@uiowa.edu.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2023 Jan; Vol. 197, pp. 107698. Date of Electronic Publication: 2022 Nov 28.
DOI: 10.1016/j.nlm.2022.107698
Abstrakt: Autism with co-occurring exceptional cognitive ability is often accompanied by severe internalizing symptoms and feelings of inadequacy. Whether cognitive ability also translates into greater risk for suicidal ideation is unclear. To investigate this urgent question, we examined two samples of high-ability autistic individuals for factors that were predictive of suicidal ideation. In the first sample (N = 1,074 individuals seen at a clinic specializing in gifted/talented youth), we observed a striking excess of parent-reported suicidal ideation in autistic individuals with IQ ≥ 120 (Odds Ratio = 5.9, p=0.0007). In a separate sample of SPARK participants, we confirmed higher rates of suicidal thoughts compared to non-autistic children from the ABCD cohort (combined N = 16,049, Odds Ratio = 6.8, p<2.2e-16), and further that autistic children with suicidal thoughts had significantly higher cognitive ability (p<2.2e-16) than those without. Elevated polygenic scores (PGS) for cognitive performance were associated with increased suicidal thoughts (N = 1,983, Z=2.16,p=0.03), with PGS for educational attainment trending in the same direction (Z=1.4,p=0.17). Notably, similar results were found in parents of these autistic youth, where higher PGS for educational attainment was associated with increasing thoughts of suicide (N = 736, Z=2.28,p=0.02). Taken together, these results suggest that on a phenotypic and genetic level, increasing cognitive ability is an unexpected risk factor for suicidal ideation in individuals diagnosed with, or at risk for autism.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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