| Autor: |
Borsoi FT; Department of Food Engineering and Chemical Engineering, Santa Catarina State University, Pinhalzinho, Brazil., Bonadiman BDSR; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil., Marafon F; Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil., Fischer DLO; Sul-rio-grandense Federal Institute of Education, Science and Technology, Pelotas, Brazil., Bagatini MD; Academic Coordination, Federal University of Fronteira Sul, Chapecó, Brazil., Kempka AP; Department of Food Engineering and Chemical Engineering, Santa Catarina State University, Pinhalzinho, Brazil. |
| Abstrakt: |
In this study, phytochemical profiling, cytotoxic potential, antitumoral activity, and α-amylase and α-glucosidase inhibition capacity of extracts of seed and pulp of Eugenia uniflora L. fruits were investigated. The extracts were obtained using a cellulase complex and the phenolic compounds were quantified. The cytotoxic potential and antitumoral activity were evaluated using peripheral blood mononuclear cells and melanoma-type tumor cells, respectively. The α-amylase and α-glucosidase inhibition capacity was determined. For all extracts, the compounds identified and quantified were salicylic acid, protocatechuic acid, gallic acid and, myricitrin. For extract of pulp, ellagic and p-coumaric acids were also identified and quantified. The extracts do not show cytotoxicity in peripheral blood mononuclear cells. Extract of seed was able to decrease cell viability in melanoma-type tumor cells within 24 h of exposure. The concentration 5 µg mL -1 of extracts inhibited 7.73% of α-amylase and 15.34% of α-glucosidase. The Pitanga extracts presents substances with biological activities. |
