White-matter correlates of anxiety: The contribution of the corpus-callosum to the study of anxiety and stress-related disorders.

Autor: Saar-Ashkenazy R; Faculty of Social-Work, Ashkelon Academic College, Ashkelon, Israel.; Department of Brain and Cognitive Neuroscience, The Zlotowski Center for Neuroscience Ben-Gurion University of the Negev, Beer-Sheva, Israel., Guez J; Department of Psychology, Achva Academic College, Beer-Tuvia Regional Council, Shikmim, Israel.; Beer-Sheva Mental Health Center, Shikmim, Israel., Jacob Y; Department of Psychiatry, Depression and Anxiety Center for Discovery and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Veksler R; Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Cohen JE; Sharett Institute of Oncology and The Wohl Institute for Translational Medicine, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Shelef I; Department of Radiology, Soroka University Medical Center, Beer-Sheva, Israel., Friedman A; Department of Brain and Cognitive Neuroscience, The Zlotowski Center for Neuroscience Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Benifla M; Department of Pediatric Neurosurgery, Rambam Health Care Campus, Haifa, Israel.
Jazyk: angličtina
Zdroj: International journal of methods in psychiatric research [Int J Methods Psychiatr Res] 2023 Dec; Vol. 32 (4), pp. e1955. Date of Electronic Publication: 2022 Nov 29.
DOI: 10.1002/mpr.1955
Abstrakt: Objectives: Traumatic stress has been associated with increased risk for brain alterations and development of anxiety disorders. Studies conducted in posttraumatic patients have shown white-mater volume and diffusion alterations in the corpus-callosum. Decreased cognitive performance has been demonstrated in acute stress disorder and posttraumatic patients. However, whether cognitive alterations result from stress related neuropathology or reflect a predisposition is not known. In the current study, we examined in healthy controls, whether individual differences in anxiety are associated with those cognitive and brain alterations reported in stress related pathologies.
Methods: Twenty healthy volunteers were evaluated for anxiety using the state-trait inventory (STAI), and were tested for memory performance. Brain imaging was employed to extract volumetric and diffusion characteristics of the corpus-callosum.
Results: Significant correlations were found between trait anxiety and all three diffusion parameters (fractional-anisotropy, mean and radial-diffusivity). Associative-memory performance and corpus-callosum volume were also significantly correlated.
Conclusion: We suggest that cognitive and brain alterations, as tested in the current work and reported in stress related pathologies, are present early and possibly persist throughout life. Our findings support the hypothesis that individual differences in trait anxiety predispose individuals towards negative cognitive outcomes and brain alterations, and potentially to stress related disorders.
(© 2022 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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