A Novel Method for Detecting Lanthanum Phosphate Deposition in the Gastroduodenal Mucosa Using Fluorescence Microscopy.
| Autor: | Iwamuro M; Department of Gastroenterology and Hepatology, Okayama University Hospital, Okayama, JPN., Urata H; Central Research Laboratory, Okayama University Medical School, Okayama, JPN., Iwasa S; Central Research Laboratory, Okayama University Medical School, Okayama, JPN., Tanaka T; Department of Pathology, Okayama University Hospital, Okayama, JPN., Kawahara Y; Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital, Okayama, JPN., Okada H; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JPN. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Oct 26; Vol. 14 (10), pp. e30729. Date of Electronic Publication: 2022 Oct 26 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.30729 |
| Abstrakt: | Diagnostic utility of fluorescence microscopy for lanthanum phosphate deposition in the gastrointestinal mucosa has not been reported previously. In this study, we comparatively assessed the light, electron, and fluorescence microscopy features of gastroduodenal lanthanum phosphate deposition in 10 patients with deposits in the stomach and 5 patients with deposits in the duodenum. During light microscopy, lanthanum deposits were observed as dark-brown, needle-shaped, or crystalloid structures and pale red amorphous materials. During electron microscopy, the deposited material appeared as bright aggregates. Fluorescence microscopy also revealed lanthanum deposits as bright areas under green, red, and blue filters. The deposits were more easily recognizable on electron and fluorescence microscopy than on light microscopy. Furthermore, during fluorescence microscopy, the green filter provided the most clear visualization of lanthanum phosphate. In conclusion, fluorescence microscopy with a green filter is useful in determining the degree and extent of lanthanum deposition in the gastroduodenal mucosa. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Iwamuro et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|