Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia.

Autor: Askapuli A; School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.; National Center for Biotechnology, Astana, Kazakhstan.; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.; Department of Integrative Biology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Vilar M; The Genographic Project, National Geographic Society, Washington, DC, United States of America.; Department of Anthropology, University of Maryland, College Park, Maryland, United States of America., Garcia-Ortiz H; Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico., Zhabagin M; School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.; National Center for Biotechnology, Astana, Kazakhstan.; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan., Sabitov Z; L.N. Gumilyov Eurasian National University, Astana, Kazakhstan., Akilzhanova A; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan., Ramanculov E; School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.; National Center for Biotechnology, Astana, Kazakhstan., Schamiloglu U; School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan., Martinez-Hernandez A; Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico., Contreras-Cubas C; Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico., Barajas-Olmos F; Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico., Schurr TG; Department of Anthropology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Zhumadilov Z; National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.; School of Medicine, Nazarbayev University, Astana, Kazakhstan., Flores-Huacuja M; Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico., Orozco L; Immunogenomics and Metabolic Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico., Hawks J; Department of Integrative Biology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Department of Anthropology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Saitou N; Population Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan.; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.; Advanced Medical Research Center, Faculty of Medicine, University of the Ryukyus, Okinawa Ken, Japan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Nov 29; Vol. 17 (11), pp. e0277771. Date of Electronic Publication: 2022 Nov 29 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0277771
Abstrakt: As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex history for this population. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. Our analyses further indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2022 Askapuli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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