Adiposity in the older population and the risk of dementia: The Rotterdam Study.

Autor:	Mooldijk SS; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., de Crom TOE; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Ikram MK; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Voortman T; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 May; Vol. 19 (5), pp. 2047-2055. Date of Electronic Publication: 2022 Nov 29.
DOI:	10.1002/alz.12888
Abstrakt:	Introduction: We determined associations of total and regional adiposity with incident dementia among older adults. Methods: Within the population-based Rotterdam Study, adiposity was measured as total, android, and gynoid fat mass using dual-energy X-ray absorptiometry in 3408 men and 4563 women, every 3 to 6 years between 2002 and 2016. Incident dementia was recorded until 2020. Results: Higher adiposity measures were associated with a decreased risk of dementia in both sexes. After excluding the first 5 years of follow-up, only the association of gynoid fat among women remained significant (hazard ratio 0.85 [95% confidence interval 0.75-0.97] per standard deviation increase). No major differences in trajectories of adiposity measures were observed between dementia cases and dementia-free controls. Discussion: Higher total and regional fat mass related to a decreased risk of dementia. These results may be explained by reverse causality, although a protective effect of adiposity cannot be excluded. Highlights: Total and regional adiposity were assessed using dual-energy X-ray absorptiometry scans in 7971 older adults. All adiposity measures were associated with a decreased risk of dementia. The results suggest a beneficial effect of gynoid fat on the risk of dementia in women. Reverse causation and competing risk may explain these inverse associations. (© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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